Abstract
A cyclic peptide role model was used for the design and synthesis of a new class of biologically active and α4-selective integrin antagonists (e.g. 1) based on β-D-mannose. These carbohydrate-based peptidomimetics were synthesized to include the functional groups of their cyclic peptide precursors without the redundant amide backbone.
Original language | English |
---|---|
Pages (from-to) | 3870-3873 |
Number of pages | 4 |
Journal | Angewandte Chemie International Edition in English |
Volume | 40 |
Issue number | 20 |
DOIs | |
State | Published - 15 Oct 2001 |
Keywords
- Carbohydrates
- Drug research
- Integrins
- Peptidomimetics