Design, synthesis, and biological evaluation of α4β1 integrin antagonists based on β-D-mannose as rigid scaffold

Jürgen Boer, Dirk Gottschling, Anja Schuster, Bernhard Holzmann, Horst Kessler

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

A cyclic peptide role model was used for the design and synthesis of a new class of biologically active and α4-selective integrin antagonists (e.g. 1) based on β-D-mannose. These carbohydrate-based peptidomimetics were synthesized to include the functional groups of their cyclic peptide precursors without the redundant amide backbone.

Original languageEnglish
Pages (from-to)3870-3873
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume40
Issue number20
DOIs
StatePublished - 15 Oct 2001

Keywords

  • Carbohydrates
  • Drug research
  • Integrins
  • Peptidomimetics

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