Design and self-assembly of DNA into nanoscale 3D shapes

Shawn M. Douglas; Hendrik Dietz; Tim Liedl; Björn Högberg; Franziska Graf; Adam H. Marblestone; Surat Teerapittayanon; Alejandro Vazquez; George M. Church; William M. Shih

Design and self-assembly of DNA into nanoscale 3D shapes

Shawn M. Douglas, Hendrik Dietz, Tim Liedl, Björn Högberg, Franziska Graf, Adam H. Marblestone, Surat Teerapittayanon, Alejandro Vazquez, George M. Church, William M. Shih

Broad Institute of Harvard University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

We have developed a general method for solving a key challenge for nanotechnology: programmable self-assembly of complex, three-dimensional nanostructures [Douglas, Dietz, et al. 2009]. Previously, scaffolded DNA origami has been used to build arbitrary flat shapes 100 nm in diameter and almost twice the mass of a ribosome [Rothemund 2006]. Now we have succeeded in building custom three-dimensional structures that can be conceived as stacks of nearly flat layers of DNA. Successful extension from two dimensions to three dimensions in this way depended critically on calibration of folding conditions. A general capability for building complex, three-dimensional nanostructures will be of great interest to biologists, chemists, physicists, engineers, and computer scientists.

Original language	English
Title of host publication	SIGGRAPH 2009
Subtitle of host publication	Talks, SIGGRAPH '09
State	Published - 2009
Externally published	Yes
Event	SIGGRAPH 2009: Talks, SIGGRAPH '09 - New Orleans, LA, United States Duration: 3 Aug 2009 → 7 Aug 2009

Publication series

Name	SIGGRAPH 2009: Talks, SIGGRAPH '09

Conference

Conference	SIGGRAPH 2009: Talks, SIGGRAPH '09
Country/Territory	United States
City	New Orleans, LA
Period	3/08/09 → 7/08/09

Cite this

@inproceedings{06f2a556b3e349739abfe6b179c8ce5f,

title = "Design and self-assembly of DNA into nanoscale 3D shapes",

abstract = "We have developed a general method for solving a key challenge for nanotechnology: programmable self-assembly of complex, three-dimensional nanostructures [Douglas, Dietz, et al. 2009]. Previously, scaffolded DNA origami has been used to build arbitrary flat shapes 100 nm in diameter and almost twice the mass of a ribosome [Rothemund 2006]. Now we have succeeded in building custom three-dimensional structures that can be conceived as stacks of nearly flat layers of DNA. Successful extension from two dimensions to three dimensions in this way depended critically on calibration of folding conditions. A general capability for building complex, three-dimensional nanostructures will be of great interest to biologists, chemists, physicists, engineers, and computer scientists.",

author = "Douglas, {Shawn M.} and Hendrik Dietz and Tim Liedl and Bj{\"o}rn H{\"o}gberg and Franziska Graf and Marblestone, {Adam H.} and Surat Teerapittayanon and Alejandro Vazquez and Church, {George M.} and Shih, {William M.}",

year = "2009",

language = "English",

isbn = "9781605588346",

series = "SIGGRAPH 2009: Talks, SIGGRAPH '09",

booktitle = "SIGGRAPH 2009",

note = "SIGGRAPH 2009: Talks, SIGGRAPH '09 ; Conference date: 03-08-2009 Through 07-08-2009",

}

TY - GEN

T1 - Design and self-assembly of DNA into nanoscale 3D shapes

AU - Douglas, Shawn M.

AU - Dietz, Hendrik

AU - Liedl, Tim

AU - Högberg, Björn

AU - Graf, Franziska

AU - Marblestone, Adam H.

AU - Teerapittayanon, Surat

AU - Vazquez, Alejandro

AU - Church, George M.

AU - Shih, William M.

PY - 2009

Y1 - 2009

N2 - We have developed a general method for solving a key challenge for nanotechnology: programmable self-assembly of complex, three-dimensional nanostructures [Douglas, Dietz, et al. 2009]. Previously, scaffolded DNA origami has been used to build arbitrary flat shapes 100 nm in diameter and almost twice the mass of a ribosome [Rothemund 2006]. Now we have succeeded in building custom three-dimensional structures that can be conceived as stacks of nearly flat layers of DNA. Successful extension from two dimensions to three dimensions in this way depended critically on calibration of folding conditions. A general capability for building complex, three-dimensional nanostructures will be of great interest to biologists, chemists, physicists, engineers, and computer scientists.

AB - We have developed a general method for solving a key challenge for nanotechnology: programmable self-assembly of complex, three-dimensional nanostructures [Douglas, Dietz, et al. 2009]. Previously, scaffolded DNA origami has been used to build arbitrary flat shapes 100 nm in diameter and almost twice the mass of a ribosome [Rothemund 2006]. Now we have succeeded in building custom three-dimensional structures that can be conceived as stacks of nearly flat layers of DNA. Successful extension from two dimensions to three dimensions in this way depended critically on calibration of folding conditions. A general capability for building complex, three-dimensional nanostructures will be of great interest to biologists, chemists, physicists, engineers, and computer scientists.

UR - http://www.scopus.com/inward/record.url?scp=73049112272&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:73049112272

SN - 9781605588346

T3 - SIGGRAPH 2009: Talks, SIGGRAPH '09

BT - SIGGRAPH 2009

T2 - SIGGRAPH 2009: Talks, SIGGRAPH '09

Y2 - 3 August 2009 through 7 August 2009

ER -

Design and self-assembly of DNA into nanoscale 3D shapes

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