Design and evaluation of magnetic fields for nanoparticle drug targeting in cancer

Bernhard Gleich; Nicole Hellwig; Hanna Bridell; Roland Jurgons; Christian Seliger; Christoph Alexiou; Bernhard Wolf; Thomas Weyh

doi:10.1109/TNANO.2007.891829

Design and evaluation of magnetic fields for nanoparticle drug targeting in cancer

Bernhard Gleich, Nicole Hellwig, Hanna Bridell, Roland Jurgons, Christian Seliger, Christoph Alexiou, Bernhard Wolf, Thomas Weyh

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Abstract

The retention of superparamagnetic nanoparticles under the influence of a high-gradient magnetic field was investigated. A simulation algorithm for prediction of the particle's trajectories and, therefore, the total amount of adhered particles in an artificial vessel was developed. Comparisons between in vitro experiments and simulations showed that the required experimental magnetic moments were greater than the theoretically estimated magnetic moments. This paper presents a method for investigating magnetic fields and for determining the magnetic moment of particles by simulation of their trajectories. The detailed function of magnetic drug targeting is of great importance in animal studies and in human therapies.

Original language	English
Pages (from-to)	164-169
Number of pages	6
Journal	IEEE Transactions on Nanotechnology
Volume	6
Issue number	2
DOIs	https://doi.org/10.1109/TNANO.2007.891829
State	Published - Mar 2007

Keywords

Biomagnetics
Biomedical engineering
Cancer
Magnetostatics
Magnets

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/TNANO.2007.891829

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title = "Design and evaluation of magnetic fields for nanoparticle drug targeting in cancer",

abstract = "The retention of superparamagnetic nanoparticles under the influence of a high-gradient magnetic field was investigated. A simulation algorithm for prediction of the particle's trajectories and, therefore, the total amount of adhered particles in an artificial vessel was developed. Comparisons between in vitro experiments and simulations showed that the required experimental magnetic moments were greater than the theoretically estimated magnetic moments. This paper presents a method for investigating magnetic fields and for determining the magnetic moment of particles by simulation of their trajectories. The detailed function of magnetic drug targeting is of great importance in animal studies and in human therapies.",

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author = "Bernhard Gleich and Nicole Hellwig and Hanna Bridell and Roland Jurgons and Christian Seliger and Christoph Alexiou and Bernhard Wolf and Thomas Weyh",

note = "Funding Information: Manuscript received February 14, 2006; revised November 10, 2006. This work was supported by in part the German Ministry for Science and Education (BMBF) within the framework of nanotechnology for medical applications under Grant 13N8536. The review of this paper was arranged by Associate Editor J. Turner.",

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AU - Gleich, Bernhard

AU - Hellwig, Nicole

AU - Bridell, Hanna

AU - Jurgons, Roland

AU - Seliger, Christian

AU - Alexiou, Christoph

AU - Wolf, Bernhard

AU - Weyh, Thomas

N1 - Funding Information: Manuscript received February 14, 2006; revised November 10, 2006. This work was supported by in part the German Ministry for Science and Education (BMBF) within the framework of nanotechnology for medical applications under Grant 13N8536. The review of this paper was arranged by Associate Editor J. Turner.

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KW - Biomedical engineering

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Design and evaluation of magnetic fields for nanoparticle drug targeting in cancer

Abstract

Keywords

UN SDGs

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