@article{73266be1e912406caa0f7f173d142148,
title = "Desensitization With Imlifidase for HLA-Incompatible Deceased Donor Kidney Transplantation: A Delphi International Expert Consensus",
abstract = "Highly sensitized (HS) patients in need of kidney transplantation (KTx) typically spend a longer time waiting for compatible kidneys, are unlikely to receive an organ offer, and are at increased risk of antibody-mediated rejection (AMR). Desensitization using imlifidase, which is more rapid and removes total body immunoglobulin G (IgG) to a greater extent than other methods, enables transplantation to occur between HLA-incompatible (HLAi) donor–recipient pairs and allows patients to have greater access to KTx. However, when the project was launched there was limited data and clinical experience with desensitization in general and with imlifidase specifically. Hence, this Delphi methodology was used to reach a consensus from a multi-disciplinary team (MDT) of experts from 15 countries on the management of HS patients undergoing imlifidase HLAi from a deceased donor (DD) KTx. This Delphi consensus provides clinical practice guidance on the use of imlifidase in the end-to-end management of HS patients undergoing an HLAi DD KTx and supports centers in the development of guidelines for the utilization and integration of imlifidase into clinical practice.",
keywords = "desensitization, HLA incompatible, HLAi, imlifidase, kidney transplantation",
author = "Lucrezia Furian and Uwe Heemann and Mats Bengtsson and Oriol Bestard and Isabelle Binet and B{\"o}hmig, {Georg A.} and John Boletis and David Briggs and Claas, {Frans H.J.} and Lionel Couzi and Emanuele Cozzi and Marta Crespo and {De Vries}, {Aiko P.J.} and Fritz Diekmann and Magdalena Durlik and Denis Glotz and Ilkka Helantera and Annette Jackson and Jordan, {Stanley C.} and Dirk Kuypers and Carmen Lefaucheur and Christophe Legendre and Tomas Lorant and Umberto Maggiore and Nizam Mamode and Smaragdi Marinaki and Annick Massart and Thomas M{\"u}ller and Rainer Oberbauer and Lutz Renders and Dave Roelen and Taupin, {Jean Luc} and Ond{\v r}ej Viklick{\'y} and Angeliki Vittoraki and {de Weerd}, {Annelies E.} and Maarten Naesens",
note = "Publisher Copyright: Copyright {\textcopyright} 2025 Furian, Heemann, Bengtsson, Bestard, Binet, B{\"o}hmig, Boletis, Briggs, Claas, Couzi, Cozzi, Crespo, De Vries, Diekmann, Durlik, Glotz, Helantera, Jackson, Jordan, Kuypers, Lefaucheur, Legendre, Lorant, Maggiore, Mamode, Marinaki, Massart, M{\"u}ller, Oberbauer, Renders, Roelen, Taupin, Viklick{\'y}, Vittoraki, de Weerd and Naesens.",
year = "2024",
doi = "10.3389/ti.2024.13886",
language = "English",
volume = "37",
journal = "Transplant International",
issn = "0934-0874",
publisher = "Frontiers Media SA",
}