Der lange Weg von der positiven Familienanamnese zum Gen: Gentik des Herzinfarkets

Jeanette Erdmann; Arnika K. Wagner; Heribert Schunkert

doi:10.1002/ciuz.200900503

Der lange Weg von der positiven Familienanamnese zum Gen: Gentik des Herzinfarkets

Translated title of the contribution: Heart infarction genetics: Long way from positive family history to the gene

Jeanette Erdmann, Arnika K. Wagner, Heribert Schunkert

Clinic for Heart and Vascular Diseases

University of Lübeck

Research output: Contribution to journal › Article › peer-review

Abstract

Myocardial Infarction in a first-degree relative is an established cardiovascular risk factor. Twin and family studies revealed an estimate for heritability (h2) of up to 60 % for Myocardial Infarction. Major cardiovascular risk factors including hypercholesterinemia, hypertension and diabetes mellitus are also in part genetically determined. Several genomic variants have been identified that increase the risk for cardiovascular diseases. Genome wide association studies identified further common risk alleles that contribute to the manifestation of coronary artery disease, many by yet unknown mechanisms.

Translated title of the contribution	Heart infarction genetics: Long way from positive family history to the gene
Original language	German
Pages (from-to)	288-295
Number of pages	8
Journal	Chemie in Unserer Zeit
Volume	43
Issue number	5
DOIs	https://doi.org/10.1002/ciuz.200900503
State	Published - Oct 2009

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abstract = "Myocardial Infarction in a first-degree relative is an established cardiovascular risk factor. Twin and family studies revealed an estimate for heritability (h2) of up to 60 % for Myocardial Infarction. Major cardiovascular risk factors including hypercholesterinemia, hypertension and diabetes mellitus are also in part genetically determined. Several genomic variants have been identified that increase the risk for cardiovascular diseases. Genome wide association studies identified further common risk alleles that contribute to the manifestation of coronary artery disease, many by yet unknown mechanisms.",

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Der lange Weg von der positiven Familienanamnese zum Gen: Gentik des Herzinfarkets

Abstract

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