Depletionsstudien zur Essentialität von Blei an wachsenden Ratten.

Translated title of the contribution: Depletion studies on the essentiality of lead in growing rats

A. M. Reichlmayr-Lais, M. Kirchgessner

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


In model studies with rats it was tested whether symptoms of deficiency could be induced if only lead was removed from an optimal composed diet. For this purpose, one growth experiment and one experiment over generations were conducted. In both experiments depletion diets were fed with a lead concentration of 45 +/- 5 ppb, whereas the control diet was supplemented with 1 ppm lead. In the growth experiment there were no differences in weight and hematological criteria between lead-depleted rats and control rats after 30 days. Similarly in the experiment over generation neither the mother p0 nor the young rats of the f1-generation showed changes in growth rate. However, hematological abnormalities could be measured in these rats of the f1-generation at the day of weaning. In comparison with the control rats the lead-depleted rats showed reduced values of Hct by about 11%, Hb by about 15% and MCV by about 9%. Therefore, these experiments demonstrated first physiological abnormalities as the result of lead-depletion, findings which indicate the essentiality of lead.

Translated title of the contributionDepletion studies on the essentiality of lead in growing rats
Original languageGerman
Pages (from-to)731-737
Number of pages7
JournalArchiv für Tierernährung
Issue number11-12
StatePublished - Dec 1981


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