Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography

Katharina Hellbach; Andrea Baehr; Fabio De Marco; Konstantin Willer; Lukas B. Gromann; Julia Herzen; Michaela Dmochewitz; Sigrid Auweter; Alexander A. Fingerle; Peter B. Noël; Ernst J. Rummeny; Andre Yaroshenko; Hanns Ingo Maack; Thomas Pralow; Hendrik Van Der Heijden; Nataly Wieberneit; Roland Proksa; Thomas Koehler; Karsten Rindt; Tobias J. Schroeter; Juergen Mohr; Fabian Bamberg; Birgit Ertl-Wagner; Franz Pfeiffer; Maximilian F. Reiser

doi:10.1038/s41598-018-20985-y

Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography

Katharina Hellbach, Andrea Baehr, Fabio De Marco, Konstantin Willer, Lukas B. Gromann, Julia Herzen, Michaela Dmochewitz, Sigrid Auweter, Alexander A. Fingerle, Peter B. Noël, Ernst J. Rummeny, Andre Yaroshenko, Hanns Ingo Maack, Thomas Pralow, Hendrik Van Der Heijden, Nataly Wieberneit, Roland Proksa, Thomas Koehler, Karsten Rindt, Tobias J. SchroeterJuergen Mohr, Fabian Bamberg, Birgit Ertl-Wagner, Franz Pfeiffer, Maximilian F. Reiser

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The aim of this study was to assess the diagnostic value of x-ray dark-field radiography to detect pneumothoraces in a pig model. Eight pigs were imaged with an experimental grating-based large-animal dark-field scanner before and after induction of a unilateral pneumothorax. Image contrast-to-noise ratios between lung tissue and the air-filled pleural cavity were quantified for transmission and dark-field radiograms. The projected area in the object plane of the inflated lung was measured in dark-field images to quantify the collapse of lung parenchyma due to a pneumothorax. Means and standard deviations for lung sizes and signal intensities from dark-field and transmission images were tested for statistical significance using Student's two-tailed t-test for paired samples. The contrast-to-noise ratio between the air-filled pleural space of lateral pneumothoraces and lung tissue was significantly higher in the dark-field (3.65 ± 0.9) than in the transmission images (1.13 ± 1.1; p = 0.002). In case of dorsally located pneumothoraces, a significant decrease (-20.5%; p > 0.0001) in the projected area of inflated lung parenchyma was found after a pneumothorax was induced. Therefore, the detection of pneumothoraces in x-ray dark-field radiography was facilitated compared to transmission imaging in a large animal model.

Original language	English
Article number	2602
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-20985-y
State	Published - 1 Dec 2018

Access to Document

10.1038/s41598-018-20985-y

Cite this

Hellbach, K., Baehr, A., De Marco, F., Willer, K., Gromann, L. B., Herzen, J., Dmochewitz, M., Auweter, S., Fingerle, A. A., Noël, P. B., Rummeny, E. J., Yaroshenko, A., Maack, H. I., Pralow, T., Van Der Heijden, H., Wieberneit, N., Proksa, R., Koehler, T., Rindt, K., ... Reiser, M. F. (2018). Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography. Scientific Reports, 8(1), Article 2602. https://doi.org/10.1038/s41598-018-20985-y

@article{281aa20263434ac8adbe85822d4b5caf,

title = "Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography",

abstract = "The aim of this study was to assess the diagnostic value of x-ray dark-field radiography to detect pneumothoraces in a pig model. Eight pigs were imaged with an experimental grating-based large-animal dark-field scanner before and after induction of a unilateral pneumothorax. Image contrast-to-noise ratios between lung tissue and the air-filled pleural cavity were quantified for transmission and dark-field radiograms. The projected area in the object plane of the inflated lung was measured in dark-field images to quantify the collapse of lung parenchyma due to a pneumothorax. Means and standard deviations for lung sizes and signal intensities from dark-field and transmission images were tested for statistical significance using Student's two-tailed t-test for paired samples. The contrast-to-noise ratio between the air-filled pleural space of lateral pneumothoraces and lung tissue was significantly higher in the dark-field (3.65 ± 0.9) than in the transmission images (1.13 ± 1.1; p = 0.002). In case of dorsally located pneumothoraces, a significant decrease (-20.5%; p > 0.0001) in the projected area of inflated lung parenchyma was found after a pneumothorax was induced. Therefore, the detection of pneumothoraces in x-ray dark-field radiography was facilitated compared to transmission imaging in a large animal model.",

author = "Katharina Hellbach and Andrea Baehr and {De Marco}, Fabio and Konstantin Willer and Gromann, {Lukas B.} and Julia Herzen and Michaela Dmochewitz and Sigrid Auweter and Fingerle, {Alexander A.} and No{\"e}l, {Peter B.} and Rummeny, {Ernst J.} and Andre Yaroshenko and Maack, {Hanns Ingo} and Thomas Pralow and {Van Der Heijden}, Hendrik and Nataly Wieberneit and Roland Proksa and Thomas Koehler and Karsten Rindt and Schroeter, {Tobias J.} and Juergen Mohr and Fabian Bamberg and Birgit Ertl-Wagner and Franz Pfeiffer and Reiser, {Maximilian F.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s).",

year = "2018",

month = dec,

day = "1",

doi = "10.1038/s41598-018-20985-y",

language = "English",

volume = "8",

journal = "Scientific Reports",

publisher = "Nature Publishing Group",

number = "1",

}

Hellbach, K, Baehr, A, De Marco, F, Willer, K, Gromann, LB, Herzen, J, Dmochewitz, M, Auweter, S, Fingerle, AA, Noël, PB, Rummeny, EJ, Yaroshenko, A, Maack, HI, Pralow, T, Van Der Heijden, H, Wieberneit, N, Proksa, R, Koehler, T, Rindt, K, Schroeter, TJ, Mohr, J, Bamberg, F, Ertl-Wagner, B, Pfeiffer, F & Reiser, MF 2018, 'Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography', Scientific Reports, vol. 8, no. 1, 2602. https://doi.org/10.1038/s41598-018-20985-y

TY - JOUR

T1 - Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography

AU - Hellbach, Katharina

AU - Baehr, Andrea

AU - De Marco, Fabio

AU - Willer, Konstantin

AU - Gromann, Lukas B.

AU - Herzen, Julia

AU - Dmochewitz, Michaela

AU - Auweter, Sigrid

AU - Fingerle, Alexander A.

AU - Noël, Peter B.

AU - Rummeny, Ernst J.

AU - Yaroshenko, Andre

AU - Maack, Hanns Ingo

AU - Pralow, Thomas

AU - Van Der Heijden, Hendrik

AU - Wieberneit, Nataly

AU - Proksa, Roland

AU - Koehler, Thomas

AU - Rindt, Karsten

AU - Schroeter, Tobias J.

AU - Mohr, Juergen

AU - Bamberg, Fabian

AU - Ertl-Wagner, Birgit

AU - Pfeiffer, Franz

AU - Reiser, Maximilian F.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The aim of this study was to assess the diagnostic value of x-ray dark-field radiography to detect pneumothoraces in a pig model. Eight pigs were imaged with an experimental grating-based large-animal dark-field scanner before and after induction of a unilateral pneumothorax. Image contrast-to-noise ratios between lung tissue and the air-filled pleural cavity were quantified for transmission and dark-field radiograms. The projected area in the object plane of the inflated lung was measured in dark-field images to quantify the collapse of lung parenchyma due to a pneumothorax. Means and standard deviations for lung sizes and signal intensities from dark-field and transmission images were tested for statistical significance using Student's two-tailed t-test for paired samples. The contrast-to-noise ratio between the air-filled pleural space of lateral pneumothoraces and lung tissue was significantly higher in the dark-field (3.65 ± 0.9) than in the transmission images (1.13 ± 1.1; p = 0.002). In case of dorsally located pneumothoraces, a significant decrease (-20.5%; p > 0.0001) in the projected area of inflated lung parenchyma was found after a pneumothorax was induced. Therefore, the detection of pneumothoraces in x-ray dark-field radiography was facilitated compared to transmission imaging in a large animal model.

AB - The aim of this study was to assess the diagnostic value of x-ray dark-field radiography to detect pneumothoraces in a pig model. Eight pigs were imaged with an experimental grating-based large-animal dark-field scanner before and after induction of a unilateral pneumothorax. Image contrast-to-noise ratios between lung tissue and the air-filled pleural cavity were quantified for transmission and dark-field radiograms. The projected area in the object plane of the inflated lung was measured in dark-field images to quantify the collapse of lung parenchyma due to a pneumothorax. Means and standard deviations for lung sizes and signal intensities from dark-field and transmission images were tested for statistical significance using Student's two-tailed t-test for paired samples. The contrast-to-noise ratio between the air-filled pleural space of lateral pneumothoraces and lung tissue was significantly higher in the dark-field (3.65 ± 0.9) than in the transmission images (1.13 ± 1.1; p = 0.002). In case of dorsally located pneumothoraces, a significant decrease (-20.5%; p > 0.0001) in the projected area of inflated lung parenchyma was found after a pneumothorax was induced. Therefore, the detection of pneumothoraces in x-ray dark-field radiography was facilitated compared to transmission imaging in a large animal model.

UR - http://www.scopus.com/inward/record.url?scp=85041803310&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-20985-y

DO - 10.1038/s41598-018-20985-y

M3 - Article

C2 - 29422512

AN - SCOPUS:85041803310

VL - 8

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 2602

ER -

Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography

Abstract

Access to Document

Other files and links

Fingerprint

Cite this