Dendrimer-Based Multinuclear Gold(I) Complexes

Peter Lange, Annette Schier, Hubert Schmidbaur

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79 Scopus citations

Abstract

In model reactions for the synthesis of phosphine-terminated tentacles of polyamine dendrimers, the amides MeNHCOC2H4PPh2, (2a) and (CH2NHCOC2H4PPh2)2 (2b) were prepared from the spacer phosphine (diphenylphosphino)propionic acid (1) and methylamine or ethylenediamine, respectively, using EDC [N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide hydrochloride] as a coupling agent. By the same procedure, the dendritic, multifunctional species DAB-PPI-(NHCOC2H4PPh2)16 (5a) and DAB-PPI-(NHCOC2H4PPh2)32 (5b) were obtained from diamrnobutane-poly(trimethyleneamine) dendrimers. The purification of products 5a,b was followed by GPC methods, and the compounds were identified by analytical and NMR spectroscopic data. Treatment of the diphenylphosphino-terminated compounds 2a,b and 5a,b with equivalent amounts of (dimethyl sulfide)gold-(I) chloride afforded the corresponding mono-, di-, hexadeca-, and dotriacontanuclear gold(I) complexes 3a,b and 6a,b, respectively, with terminal (diphenylphosphine)gold(I) chloride groups (-PPh2AuCl) in good yields as stable colorless solids. Full coverage of all ω-phosphine functions was accomplished as confirmed again by NMR spectroscopy. For further delineation of the configuration of the peptide-phosphine spacer tentacles, X-ray structure analyses were performed for MeNHCOC2H4PPh2AuCl (3a, triclinic, space group P1̄) and (CH2-NHCOC2H4PPh2AuCl)2 (3b, monoclinic, space group C2/c). The conformation of the molecules and their packing can be rationalized on the basis of intermolecular NH⋯O hydrogen bonds, which in these cases exclude intra- and intermolecular Au1⋯Au1 contacts.

Original languageEnglish
Pages (from-to)637-642
Number of pages6
JournalInorganic Chemistry
Volume35
Issue number3
DOIs
StatePublished - 1996
Externally publishedYes

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