@inproceedings{ebc2e7962bb84ea3ae6aa68f20f738a6,
title = "Deformation based morphometry analysis of serial magnetic resonance images of mouse brains",
abstract = "Deformation based morphometry is used to detect differences in in-vivo Magnetic Resonance Image (MRI) of the mouse brain obtained from two transgenic strains: TASTPM mice that over-express proteins associated with Alzheimer's disease, and wild-type mice. MRI was carried out at four time points. We compare two different methods to detect group differences in the longitudinal and cross-sectional data. Both methods are based on non-rigid registration of the images to a mouse brain atlas. The whole brain volume measurements on 27 TASTPM and wild-type animals are reproducible to within 0.4\% of whole brain volume. The agreement between different methods for measuring volumes in a serial study is shown. The ability to quantify changes in growth between strains in whole brain, hippocampus and cerebral cortex is demonstrated.",
author = "Satheesh Maheswaran and Herv{\'e} Barjat and Simon Bate and Thomas Hartkens and Hill, \{Derek L.G.\} and James, \{Michael F.\} and Lorna Tilling and Neil Upton and Jo Hajnal and Daniel Rueckert",
year = "2006",
doi = "10.1007/11784012\_8",
language = "English",
isbn = "3540356487",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "58--65",
booktitle = "Biomedical Image Registration - Third International Workshop, WBIR 2006, Proceedings",
note = "3rd International Workshop on Biomedical Image Registration, WBIR 2006 ; Conference date: 09-07-2006 Through 11-07-2006",
}