Deep eutectic solvents in countercurrent and centrifugal partition chromatography

Simon Roehrer; Franziska Bezold; Eva Marra García; Mirjana Minceva

doi:10.1016/j.chroma.2016.01.024

Deep eutectic solvents in countercurrent and centrifugal partition chromatography

Simon Roehrer, Franziska Bezold, Eva Marra García, Mirjana Minceva

Associate Professorship of Biothermodynamics

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Deep eutectic solvents (DESs) were evaluated as solvents in centrifugal partition chromatography, a liquid-liquid chromatography separation technology. To this end, the partition coefficients of ten natural compounds of different hydrophobicity were determined in non-aqueous biphasic systems containing DES. The influence of the composition of DESs and the presence of water in the biphasic system on the partition coefficient were also examined. In addition, several process relevant physical properties of the biphasic system, such as the density and viscosity of the phases, were measured. A mixture of three to four hydrophobic compounds was successfully separated in a centrifugal partition extractor using a heptane/ethanol/DES biphasic system.

Original language	English
Pages (from-to)	102-110
Number of pages	9
Journal	Journal of Chromatography A
Volume	1434
DOIs	https://doi.org/10.1016/j.chroma.2016.01.024
State	Published - 19 Feb 2016

Keywords

Centrifugal partition chromatography
Centrifugal partition extractor
Countercurrent chromatography
Deep eutectic solvents
Non-aqueous biphasic liquid systems

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10.1016/j.chroma.2016.01.024

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title = "Deep eutectic solvents in countercurrent and centrifugal partition chromatography",

abstract = "Deep eutectic solvents (DESs) were evaluated as solvents in centrifugal partition chromatography, a liquid-liquid chromatography separation technology. To this end, the partition coefficients of ten natural compounds of different hydrophobicity were determined in non-aqueous biphasic systems containing DES. The influence of the composition of DESs and the presence of water in the biphasic system on the partition coefficient were also examined. In addition, several process relevant physical properties of the biphasic system, such as the density and viscosity of the phases, were measured. A mixture of three to four hydrophobic compounds was successfully separated in a centrifugal partition extractor using a heptane/ethanol/DES biphasic system.",

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AU - Roehrer, Simon

AU - Bezold, Franziska

AU - García, Eva Marra

AU - Minceva, Mirjana

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AB - Deep eutectic solvents (DESs) were evaluated as solvents in centrifugal partition chromatography, a liquid-liquid chromatography separation technology. To this end, the partition coefficients of ten natural compounds of different hydrophobicity were determined in non-aqueous biphasic systems containing DES. The influence of the composition of DESs and the presence of water in the biphasic system on the partition coefficient were also examined. In addition, several process relevant physical properties of the biphasic system, such as the density and viscosity of the phases, were measured. A mixture of three to four hydrophobic compounds was successfully separated in a centrifugal partition extractor using a heptane/ethanol/DES biphasic system.

KW - Centrifugal partition chromatography

KW - Centrifugal partition extractor

KW - Countercurrent chromatography

KW - Deep eutectic solvents

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Deep eutectic solvents in countercurrent and centrifugal partition chromatography

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Keywords

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