Deep eutectic solvents in countercurrent and centrifugal partition chromatography

Simon Roehrer, Franziska Bezold, Eva Marra García, Mirjana Minceva

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Deep eutectic solvents (DESs) were evaluated as solvents in centrifugal partition chromatography, a liquid-liquid chromatography separation technology. To this end, the partition coefficients of ten natural compounds of different hydrophobicity were determined in non-aqueous biphasic systems containing DES. The influence of the composition of DESs and the presence of water in the biphasic system on the partition coefficient were also examined. In addition, several process relevant physical properties of the biphasic system, such as the density and viscosity of the phases, were measured. A mixture of three to four hydrophobic compounds was successfully separated in a centrifugal partition extractor using a heptane/ethanol/DES biphasic system.

Original languageEnglish
Pages (from-to)102-110
Number of pages9
JournalJournal of Chromatography A
StatePublished - 19 Feb 2016


  • Centrifugal partition chromatography
  • Centrifugal partition extractor
  • Countercurrent chromatography
  • Deep eutectic solvents
  • Non-aqueous biphasic liquid systems


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