Deducing corticotropin-releasing hormone receptor type 1 signaling networks from gene expression data by usage of genetic algorithms and graphical Gaussian models

Keyphrases

• Receptor Subtypes 100%
• Genetic Algorithm 100%
• Gene Expression Data 100%
• Signaling Network 100%
• Graphical Gaussian Model 100%
• Corticotropin Releasing Factor Receptor 1 (CRFR1) 100%
• Maximum Likelihood 50%
• Unsupervised Algorithm 50%
• Optimization Algorithm 33%
• Supervised Algorithm 33%
• Corticotropin-releasing Factor 33%
• HPA Axis 33%
• Discriminant Function 33%
• Graphical Models 16%
• Random Forest 16%
• Selection Strategy 16%
• Principal Coordinate Analysis (PCoA) 16%
• Quantitative PCR 16%
• Hyperactivity 16%
• Expression Data 16%
• Dysregulation 16%
• Genome-wide Microarray 16%
• Signaling Pathway 16%
• State-of-the-art Techniques 16%
• Neuropeptides 16%
• Anxiety Disorders 16%
• Major Depressive Disorder 16%
• New Targets 16%
• Simulated Annealing 16%
• Linear Classifier 16%
• Random Forest Method 16%
• In Vitro Model 16%
• Signal Transduction 16%
• Microarray Data 16%
• Regulated Genes 16%
• Genome-wide Expression 16%
• Psychiatric Disease 16%
• Literature Mining 16%
• Mood Disorders 16%
• Differential Regulation 16%
• Differential Expression 16%
• Pituitary 16%
• Alternative Optimization 16%
• Multivariate Methods 16%
• Univariate Methods 16%
• Negative Feedback Regulation 16%
• Greedy Selection 16%
• Expression Network 16%
• Stress Axis 16%
• AtT20 16%
• Chromosome Size 16%
• Interacting Networks 16%
• Corticotrope 16%
• Ranked Results 16%
• Multivariate Variables 16%

Biochemistry, Genetics and Molecular Biology

• Candidate Gene 100%
• Gaussian Distribution 100%
• Genetic Algorithm 100%
• Gene Expression Data 100%
• Hormone Receptor 100%
• Corticotropin-Releasing Hormone 100%
• Hypothalamus Hypophysis Adrenal System 40%
• Random Forest 40%
• Signal Transduction 20%
• Principal Component Analysis 20%
• Quantitative Reverse Transcription Polymerase Chain Reaction 20%
• Chromosome Size 20%
• Neuropeptide 20%