Decreased trabecular bone mineral density in patients with phenylketonuria measured by peripheral quantitative computed tomography

B. Schwahn; E. Mokov; K. Scheidhauer; B. Lettgen; E. Schönau

doi:10.1080/08035259850157886

Decreased trabecular bone mineral density in patients with phenylketonuria measured by peripheral quantitative computed tomography

B. Schwahn, E. Mokov, K. Scheidhauer, B. Lettgen, E. Schönau

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The bone mineral density (BMD) of 14 children, adolescents, and adults with phenylketonuria (PKU) on dietary treatment (age 5-28 y; 6F, 8M) was investigated using peripheral quantitative computed tomography (pQCT) of the distal radius. BMD of total (TBMD) and spongy bone (SBMD) were compared to those of healthy gender-, age-, weight- and height-matched controls. We found a significant decrease of SBMD in patients with PKU while TBMD was only slightly decreased, reaching no statistical significance. These results indicate minor changes of BMD in patients with PKU under treatment, which are more accentuated in the trabecular bone compartment. One additional patient who was untreated until the pQCT investigation at the age of 10 y also showed markedly decreased SBMD and TBMD.

Original language	English
Pages (from-to)	61-63
Number of pages	3
Journal	Acta Paediatrica, International Journal of Paediatrics
Volume	87
Issue number	1
DOIs	https://doi.org/10.1080/08035259850157886
State	Published - 1998
Externally published	Yes

Keywords

Bone
Children
Osteodensitometry
Osteoporosis
PKU

Access to Document

10.1080/08035259850157886

Cite this

@article{b5f08c1f45a74df6a42548eeb29af303,

title = "Decreased trabecular bone mineral density in patients with phenylketonuria measured by peripheral quantitative computed tomography",

abstract = "The bone mineral density (BMD) of 14 children, adolescents, and adults with phenylketonuria (PKU) on dietary treatment (age 5-28 y; 6F, 8M) was investigated using peripheral quantitative computed tomography (pQCT) of the distal radius. BMD of total (TBMD) and spongy bone (SBMD) were compared to those of healthy gender-, age-, weight- and height-matched controls. We found a significant decrease of SBMD in patients with PKU while TBMD was only slightly decreased, reaching no statistical significance. These results indicate minor changes of BMD in patients with PKU under treatment, which are more accentuated in the trabecular bone compartment. One additional patient who was untreated until the pQCT investigation at the age of 10 y also showed markedly decreased SBMD and TBMD.",

keywords = "Bone, Children, Osteodensitometry, Osteoporosis, PKU",

author = "B. Schwahn and E. Mokov and K. Scheidhauer and B. Lettgen and E. Sch{\"o}nau",

year = "1998",

doi = "10.1080/08035259850157886",

language = "English",

volume = "87",

pages = "61--63",

journal = "Acta Paediatrica, International Journal of Paediatrics",

issn = "0803-5253",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Decreased trabecular bone mineral density in patients with phenylketonuria measured by peripheral quantitative computed tomography

AU - Schwahn, B.

AU - Mokov, E.

AU - Scheidhauer, K.

AU - Lettgen, B.

AU - Schönau, E.

PY - 1998

Y1 - 1998

N2 - The bone mineral density (BMD) of 14 children, adolescents, and adults with phenylketonuria (PKU) on dietary treatment (age 5-28 y; 6F, 8M) was investigated using peripheral quantitative computed tomography (pQCT) of the distal radius. BMD of total (TBMD) and spongy bone (SBMD) were compared to those of healthy gender-, age-, weight- and height-matched controls. We found a significant decrease of SBMD in patients with PKU while TBMD was only slightly decreased, reaching no statistical significance. These results indicate minor changes of BMD in patients with PKU under treatment, which are more accentuated in the trabecular bone compartment. One additional patient who was untreated until the pQCT investigation at the age of 10 y also showed markedly decreased SBMD and TBMD.

AB - The bone mineral density (BMD) of 14 children, adolescents, and adults with phenylketonuria (PKU) on dietary treatment (age 5-28 y; 6F, 8M) was investigated using peripheral quantitative computed tomography (pQCT) of the distal radius. BMD of total (TBMD) and spongy bone (SBMD) were compared to those of healthy gender-, age-, weight- and height-matched controls. We found a significant decrease of SBMD in patients with PKU while TBMD was only slightly decreased, reaching no statistical significance. These results indicate minor changes of BMD in patients with PKU under treatment, which are more accentuated in the trabecular bone compartment. One additional patient who was untreated until the pQCT investigation at the age of 10 y also showed markedly decreased SBMD and TBMD.

KW - Bone

KW - Children

KW - Osteodensitometry

KW - Osteoporosis

KW - PKU

UR - http://www.scopus.com/inward/record.url?scp=0031885163&partnerID=8YFLogxK

U2 - 10.1080/08035259850157886

DO - 10.1080/08035259850157886

M3 - Article

C2 - 9510449

AN - SCOPUS:0031885163

SN - 0803-5253

VL - 87

SP - 61

EP - 63

JO - Acta Paediatrica, International Journal of Paediatrics

JF - Acta Paediatrica, International Journal of Paediatrics

IS - 1

ER -

Decreased trabecular bone mineral density in patients with phenylketonuria measured by peripheral quantitative computed tomography

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this