Decreased cortical thickness mediates the relationship between premature birth and cognitive performance in adulthood

Benita Schmitz-Koep, Josef G. Bäuml, Aurore Menegaux, Rachel Nuttall, Juliana Zimmermann, Sebastian C. Schneider, Marcel Daamen, Lukas Scheef, Henning Boecker, Claus Zimmer, Christian Gaser, Dieter Wolke, Peter Bartmann, Christian Sorg, Dennis M. Hedderich

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Cortical thickness (CTh) reflects cortical properties such as dendritic complexity and synaptic density, which are not only vulnerable to developmental disturbances caused by premature birth but also highly relevant for cognitive performance. We tested the hypotheses whether CTh in young adults is altered after premature birth and whether these aberrations are relevant for general cognitive abilities. We investigated CTh based on brain structural magnetic resonance imaging and surface-based morphometry in a large and prospectively collected cohort of 101 very premature-born adults (<32 weeks of gestation and/or birth weight [BW] below 1,500 g) and 111 full-term controls at 26 years of age. Cognitive performance was assessed by full-scale intelligence quotient (IQ) using the Wechsler Adult Intelligence Scale. CTh was reduced in frontal, parietal, and temporal associative cortices predominantly in the left hemisphere in premature-born adults compared to controls. We found a significant positive association of CTh with both gestational age and BW, particularly in the left hemisphere, and a significant negative association between CTh and intensity of neonatal treatment within limited regions bilaterally. Full-scale IQ and CTh in the left hemisphere were positively correlated. Furthermore, CTh in the left hemisphere acted as a mediator on the association between premature birth and full-scale IQ. Results provide evidence that premature born adults have widespread reduced CTh that is relevant for their general cognitive performance. Data suggest lasting reductions in cortical microstructure subserving CTh after premature birth.

Original languageEnglish
Pages (from-to)4952-4963
Number of pages12
JournalHuman Brain Mapping
Volume41
Issue number17
DOIs
StatePublished - 1 Dec 2020
Externally publishedYes

Keywords

  • brain development
  • cortical thickness
  • intelligence quotient
  • premature birth
  • structural magnetic resonance imaging

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