Deciphering the universe of genetic context-dependencies using mouse models of cancer

Chiara Falcomatà; Stefanie Bärthel; Günter Schneider; Dieter Saur; Christian Veltkamp

doi:10.1016/j.gde.2019.04.002

Deciphering the universe of genetic context-dependencies using mouse models of cancer

Chiara Falcomatà, Stefanie Bärthel, Günter Schneider, Dieter Saur, Christian Veltkamp

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Molecular profiling of cancer patients and modelling of human cancer in mice revealed cell type and tissue-specific differences in tumor development and evolution. However, the context-dependent determinants of cancer remain poorly understood. A systematic characterization of the biological underpinnings of context-specificity will, therefore, be pivotal to design more effective therapies. In this review article, we focus on recent advances on molecular, cellular and microenvironmental aspects of context-dependency. We highlight new strategies to study this phenomenon in tumorigenesis and tumor evolution. Notably, we elucidate tissue and cell type-specific signaling cues as well as tumor microenvironment niches, using novel next-generation dual and triple recombinase-based mouse models of cancer.

Original language	English
Pages (from-to)	97-104
Number of pages	8
Journal	Current Opinion in Genetics and Development
Volume	54
DOIs	https://doi.org/10.1016/j.gde.2019.04.002
State	Published - Feb 2019
Externally published	Yes

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10.1016/j.gde.2019.04.002

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title = "Deciphering the universe of genetic context-dependencies using mouse models of cancer",

abstract = "Molecular profiling of cancer patients and modelling of human cancer in mice revealed cell type and tissue-specific differences in tumor development and evolution. However, the context-dependent determinants of cancer remain poorly understood. A systematic characterization of the biological underpinnings of context-specificity will, therefore, be pivotal to design more effective therapies. In this review article, we focus on recent advances on molecular, cellular and microenvironmental aspects of context-dependency. We highlight new strategies to study this phenomenon in tumorigenesis and tumor evolution. Notably, we elucidate tissue and cell type-specific signaling cues as well as tumor microenvironment niches, using novel next-generation dual and triple recombinase-based mouse models of cancer.",

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AU - Falcomatà, Chiara

AU - Bärthel, Stefanie

AU - Schneider, Günter

AU - Saur, Dieter

AU - Veltkamp, Christian

PY - 2019/2

Y1 - 2019/2

N2 - Molecular profiling of cancer patients and modelling of human cancer in mice revealed cell type and tissue-specific differences in tumor development and evolution. However, the context-dependent determinants of cancer remain poorly understood. A systematic characterization of the biological underpinnings of context-specificity will, therefore, be pivotal to design more effective therapies. In this review article, we focus on recent advances on molecular, cellular and microenvironmental aspects of context-dependency. We highlight new strategies to study this phenomenon in tumorigenesis and tumor evolution. Notably, we elucidate tissue and cell type-specific signaling cues as well as tumor microenvironment niches, using novel next-generation dual and triple recombinase-based mouse models of cancer.

AB - Molecular profiling of cancer patients and modelling of human cancer in mice revealed cell type and tissue-specific differences in tumor development and evolution. However, the context-dependent determinants of cancer remain poorly understood. A systematic characterization of the biological underpinnings of context-specificity will, therefore, be pivotal to design more effective therapies. In this review article, we focus on recent advances on molecular, cellular and microenvironmental aspects of context-dependency. We highlight new strategies to study this phenomenon in tumorigenesis and tumor evolution. Notably, we elucidate tissue and cell type-specific signaling cues as well as tumor microenvironment niches, using novel next-generation dual and triple recombinase-based mouse models of cancer.

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SN - 0959-437X

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SP - 97

EP - 104

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

ER -

Deciphering the universe of genetic context-dependencies using mouse models of cancer

Abstract

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