Dataset on stroke infarct volume in rodents: A comparison of MRI and histological methods

Rebecca Z. Weber, Davide Bernardoni, Nora H. Rentsch, Beatriz Achón Buil, Stefanie Halliday, Mark Aurel Augath, Daniel Razansky, Christian Tackenberg, Ruslan Rust

Research output: Contribution to journalArticlepeer-review

Abstract

This dataset offers images of mouse brains impacted by photothrombotic stroke in the sensorimotor cortex published by Weber et al. NeuroImage (2024). Data is gathered using two primary techniques: (1) whole-brain ex-vivo magnetic resonance imaging (MRI) and (2) 40 µm thick coronal histological sections that undergo immunofluorescence staining with NeuroTrace. Infarct areas and volumes are assessed through MRI at two distinct time frames—three days (acute) and 28 days (chronic) following photothrombotic stroke induction. Subsequently, the brains are sectioned into 40 µm thick coronal slices, stained with NeuroTrace, and imaged as whole sections. The dataset holds considerable value for reuse, particularly for researchers focused on stroke volume estimation methods as well as those interested in comparing the efficacy of MRI and histological techniques.

Original languageEnglish
Article number110188
JournalData in Brief
Volume53
DOIs
StatePublished - Apr 2024
Externally publishedYes

Keywords

  • Histology
  • Ischemia
  • MRI
  • Preclinical stroke research
  • Stroke outcome
  • Stroke volume

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