Abstract
Of 157 patients with Hodgkin's disease treated between 1970 and 1981 an assessment of the clinical course was possible in 134 cases. Remissions were achieved in 120 patients (89%). 51 patients (43%) relapsed subsequently. The highest relapse rates were seen in advanced stages of the disease and in patients with unfavorable histological subgroups (mixed cellularity and lymphocyte depletion). Second remissions were achieved in 40 patients (78%), the remission being complete in 33 cases (65%). Patients who had received radiation therapy primarily, responded significantly better to secondary treatment than patients who had received chemotherapy initially. The predicted five-year survival rate is 70% for patients with complete remission after relapse and 34% for patients with partial remission. Though a relapse of Hodgkin's disease can frequently be treated with curative outcome, patients with certain high-risk factors (e.g. large mediastinal tumor, stage III2, lymphocyte depletion histology) need more intensive induction therapy.
| Translated title of the contribution | Relapse in Hodgkin's disease: Incidence, therapy and prognosis in a series of 134 patients |
|---|---|
| Original language | German |
| Pages (from-to) | 326-332 |
| Number of pages | 7 |
| Journal | Wiener Klinische Wochenschrift |
| Volume | 95 |
| Issue number | 10 |
| State | Published - 1983 |
| Externally published | Yes |