Das Pankreaskarzinom: Klinische Projekte der onkologischen Studiengruppen in Deutschland (ACO, AIO und ARO)

Translated title of the contribution: Pancreatic cancer: Clinical research projects of the German oncology groups (ACO, AIO, and ARO)

Jana K. Striefler, Timm M. Reissig, Volker Kunzmann, C. Benedikt Westphalen, Stefan Böck, Thomas J. Ettrich, Manfred P. Lutz, Dirk T. Waldschmidt, Thomas Brunner, Waldemar Uhl, Marianne Sinn, Jens T. Siveke

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: The incidence of pancreatic cancer (PC) is increasing. Due to a combination of therapeutic resistance and to advanced disease already at diagnosis, PC remains one of the most fatal malignant solid tumors with a 5-year survival rate of only 8–9%. Objectives: The German oncology study groups offer a broad portfolio of clinical trials. We present the most current projects of Arbeitsgemeinschaft Chirurgische Onkologie (ACO), Arbeitsgemeinschaft Internistische Onkologie (AIO), and Arbeitsgemeinschaft Radiologische Onkologie (ARO) in PC including recruiting studies as well as those envisaged or recently completed. Results: Combination chemotherapy is still the backbone of PC therapy. In localized disease, curatively intended resection followed by adjuvant chemotherapy remains standard in fit patients (e.g., modified FOLFIRINOX, gemcitabine-based). In addition, clinical trial activities focus on the role of perioperative therapy in PC. Recent clinical trials analyze the benefit in the (borderline) resectable (NEONAX), locally advanced (NEOLAP), and oligometastatic (METAPANC, HOLIPANC) setting. In metastatic PC, intensified chemotherapeutic protocols and combined epigenetic and immune targeting concepts are currently being evaluated. Conclusion: Taking into account the relevant therapeutic resistance of PC, new therapeutic concepts are needed to further ameliorate the prognosis. The role of perioperative therapy needs to be further clarified and is the objective of recent studies.

Translated title of the contributionPancreatic cancer: Clinical research projects of the German oncology groups (ACO, AIO, and ARO)
Original languageGerman
Pages (from-to)30-35
Number of pages6
JournalOnkologe
Volume28
DOIs
StatePublished - Feb 2022
Externally publishedYes

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