Das Komplementsystem und dessen mögliche Beteiligung an der Pathogenese der altersabhängigen Makuladegeneration (AMD)

P. Charbel Issa; H. P.N. Scholl; F. G. Holz; P. Knolle; C. Kurts

doi:10.1007/s00347-005-1269-4

Das Komplementsystem und dessen mögliche Beteiligung an der Pathogenese der altersabhängigen Makuladegeneration (AMD)

Translated title of the contribution: The complement system and its possible role in the pathogenesis of age-related macular degeneration (AMD)

P. Charbel Issa
, H. P.N. Scholl
, F. G. Holz
, P. Knolle
, C. Kurts

Rheinische Friedrich-Wilhelms-Universität Bonn

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

The discovery of the complement factor H (CFH) polymorphism in age-related macular degeneration (AMD) strongly suggests a causative role of the complement system in the pathogenesis of this disease. The complement system is part of the innate immune system and is closely associated with the cellular response and the adaptive immune system. This article provides an overview of the complement system and, taking the new data into account, of possible immunopathogenetic processes in AMD.

Translated title of the contribution	The complement system and its possible role in the pathogenesis of age-related macular degeneration (AMD)
Original language	German
Pages (from-to)	1036-1042
Number of pages	7
Journal	Ophthalmologe
Volume	102
Issue number	11
DOIs	https://doi.org/10.1007/s00347-005-1269-4
State	Published - Nov 2005
Externally published	Yes

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10.1007/s00347-005-1269-4

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title = "Das Komplementsystem und dessen m{\"o}gliche Beteiligung an der Pathogenese der altersabh{\"a}ngigen Makuladegeneration (AMD)",

abstract = "The discovery of the complement factor H (CFH) polymorphism in age-related macular degeneration (AMD) strongly suggests a causative role of the complement system in the pathogenesis of this disease. The complement system is part of the innate immune system and is closely associated with the cellular response and the adaptive immune system. This article provides an overview of the complement system and, taking the new data into account, of possible immunopathogenetic processes in AMD.",

keywords = "Age-related macular degeneration (AMD), Complement factor H, Complement system, Immunology, Pathogenesis",

author = "\{Charbel Issa\}, P. and Scholl, \{H. P.N.\} and Holz, \{F. G.\} and P. Knolle and C. Kurts",

year = "2005",

month = nov,

doi = "10.1007/s00347-005-1269-4",

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volume = "102",

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T1 - Das Komplementsystem und dessen mögliche Beteiligung an der Pathogenese der altersabhängigen Makuladegeneration (AMD)

AU - Charbel Issa, P.

AU - Scholl, H. P.N.

AU - Holz, F. G.

AU - Knolle, P.

AU - Kurts, C.

PY - 2005/11

Y1 - 2005/11

N2 - The discovery of the complement factor H (CFH) polymorphism in age-related macular degeneration (AMD) strongly suggests a causative role of the complement system in the pathogenesis of this disease. The complement system is part of the innate immune system and is closely associated with the cellular response and the adaptive immune system. This article provides an overview of the complement system and, taking the new data into account, of possible immunopathogenetic processes in AMD.

AB - The discovery of the complement factor H (CFH) polymorphism in age-related macular degeneration (AMD) strongly suggests a causative role of the complement system in the pathogenesis of this disease. The complement system is part of the innate immune system and is closely associated with the cellular response and the adaptive immune system. This article provides an overview of the complement system and, taking the new data into account, of possible immunopathogenetic processes in AMD.

KW - Age-related macular degeneration (AMD)

KW - Complement factor H

KW - Complement system

KW - Immunology

KW - Pathogenesis

UR - https://www.scopus.com/pages/publications/27744559546

U2 - 10.1007/s00347-005-1269-4

DO - 10.1007/s00347-005-1269-4

M3 - Übersichtsartikel

C2 - 16215754

AN - SCOPUS:27744559546

SN - 0941-293X

VL - 102

SP - 1036

EP - 1042

JO - Ophthalmologe

JF - Ophthalmologe

IS - 11

ER -

Das Komplementsystem und dessen mögliche Beteiligung an der Pathogenese der altersabhängigen Makuladegeneration (AMD)

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