@article{8515a0dbbf7f4cabaea7445937e79ee1,
title = "D{"}2R striatopallidal neurons inhibit both locomotor and drug reward processes",
abstract = "The specific functions of dopamine D{"}2 receptor-positive (D{"}2R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D{"}2R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D{"}2R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.",
author = "Durieux, {Pierre F.} and Bertrand Bearzatto and Stefania Guiducci and Thorsten Buch and Ari Waisman and Michele Zoli and Schiffmann, {Serge N.} and {De Kerchove D'Exaerde}, Alban",
note = "Funding Information: We thank M. Picciotto for helpful and critical comments on the manuscript and D. Houtteman, S. Laghmiri and L. Cuvelier for expert technical assistance. P.F.D. is Research Fellow of the Fonds de la Recherche Scientifique (bourse de doctorat Fonds de la Recherche Scientifique) and A.d.K.d.E. is a Research Associate of the Fonds de la Recherche Scientifique (Belgium). This study was supported by Fondation M{\'e}dicale Reine Elisabeth (Belgium), Fonds de la Recherche Scientifique (Belgium), Fonds d{\textquoteright}Encouragement {\`a} la Recherche from the Universit{\'e} Libre de Bruxelles, Action de Recherche Concert{\'e}e from the Communaut{\'e} Franc¸aise Wallonie Bruxelles and Ministero Italiano dell{\textquoteright}Universit{\`a} e della Ricerca (grant number PRIN20072BTSR2) to M.Z.",
year = "2009",
month = apr,
doi = "10.1038/nn.2286",
language = "English",
volume = "12",
pages = "393--395",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Research",
number = "4",
}