Cytotoxicity and sterilization resistance of electronic components for disposable smart biomedical devices

Valerie M.K. Werner, Daniel Strömsdörfer, Viet Nga Bui, Niklas Von Wittenburg, Markus Eblenkamp

Research output: Contribution to journalArticlepeer-review

Abstract

The design of Smart Biomedical Devices will be a defining element of future research in the context of intelligent medical devices for the Internet of Medical Things (IoMT). A prerequisite for serving the disposable market is the use of cost-effective electronic components and the highest reliability of the developed products in terms of biocompatibility and bioprotection. In the study, resistors, capacitors, and light-emitting diodes, different in their materials and construction forms, were examined. The selected types represented electronic components as they are commonly installed on electronic system from the segment of low-cost standard components. These were subjected to steam sterilization with up to 50 cycles, gamma sterilization, and a CCK-8 assay to test in vitro cytotoxicity. Functional failure could not be determined for any component. Gamma sterilization did not result in significant changes in resistance values, but in capacitors with barium titanate as dielectric. Non-cytotoxic electronic components could be identified. The results show that certain electronic standard components are suitable for disposable Smart Biomedical Devices.

Original languageEnglish
Pages (from-to)297-301
Number of pages5
JournalCurrent Directions in Biomedical Engineering
Volume5
Issue number1
DOIs
StatePublished - 1 Sep 2019

Keywords

  • Biocompatibility
  • Smart Medical Devices
  • cytotoxicity
  • electronic components
  • sterilization

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