TY - JOUR
T1 - Cytotoxicity and sterilization resistance of electronic components for disposable smart biomedical devices
AU - Werner, Valerie M.K.
AU - Strömsdörfer, Daniel
AU - Nga Bui, Viet
AU - Von Wittenburg, Niklas
AU - Eblenkamp, Markus
N1 - Publisher Copyright:
© 2019 by Walter de Gruyter Berlin/Boston.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - The design of Smart Biomedical Devices will be a defining element of future research in the context of intelligent medical devices for the Internet of Medical Things (IoMT). A prerequisite for serving the disposable market is the use of cost-effective electronic components and the highest reliability of the developed products in terms of biocompatibility and bioprotection. In the study, resistors, capacitors, and light-emitting diodes, different in their materials and construction forms, were examined. The selected types represented electronic components as they are commonly installed on electronic system from the segment of low-cost standard components. These were subjected to steam sterilization with up to 50 cycles, gamma sterilization, and a CCK-8 assay to test in vitro cytotoxicity. Functional failure could not be determined for any component. Gamma sterilization did not result in significant changes in resistance values, but in capacitors with barium titanate as dielectric. Non-cytotoxic electronic components could be identified. The results show that certain electronic standard components are suitable for disposable Smart Biomedical Devices.
AB - The design of Smart Biomedical Devices will be a defining element of future research in the context of intelligent medical devices for the Internet of Medical Things (IoMT). A prerequisite for serving the disposable market is the use of cost-effective electronic components and the highest reliability of the developed products in terms of biocompatibility and bioprotection. In the study, resistors, capacitors, and light-emitting diodes, different in their materials and construction forms, were examined. The selected types represented electronic components as they are commonly installed on electronic system from the segment of low-cost standard components. These were subjected to steam sterilization with up to 50 cycles, gamma sterilization, and a CCK-8 assay to test in vitro cytotoxicity. Functional failure could not be determined for any component. Gamma sterilization did not result in significant changes in resistance values, but in capacitors with barium titanate as dielectric. Non-cytotoxic electronic components could be identified. The results show that certain electronic standard components are suitable for disposable Smart Biomedical Devices.
KW - Biocompatibility
KW - Smart Medical Devices
KW - cytotoxicity
KW - electronic components
KW - sterilization
UR - http://www.scopus.com/inward/record.url?scp=85072646046&partnerID=8YFLogxK
U2 - 10.1515/cdbme-2019-0075
DO - 10.1515/cdbme-2019-0075
M3 - Article
AN - SCOPUS:85072646046
SN - 2364-5504
VL - 5
SP - 297
EP - 301
JO - Current Directions in Biomedical Engineering
JF - Current Directions in Biomedical Engineering
IS - 1
ER -