Cytotoxic profile and peculiar reactivity with biomolecules of a novel "rule-breaker" iodidoplatinum(II) complex

Luigi Messori, Angela Casini, Chiara Gabbiani, Elena Michelucci, Leticia Cubo, Carla Ríos-Luci, José M. Padrón, Carmen Navarro-Ranninger, Adoracion G. Quiroga

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably, this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalACS Medicinal Chemistry Letters
Volume1
Issue number8
DOIs
StatePublished - 11 Nov 2010
Externally publishedYes

Keywords

  • DNA and protein interaction
  • Iodidoplatinum complex
  • cytotoxicity

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