Abstract
Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably, this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.
Original language | English |
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Pages (from-to) | 381-385 |
Number of pages | 5 |
Journal | ACS Medicinal Chemistry Letters |
Volume | 1 |
Issue number | 8 |
DOIs | |
State | Published - 11 Nov 2010 |
Externally published | Yes |
Keywords
- DNA and protein interaction
- Iodidoplatinum complex
- cytotoxicity