Cytotoxic action of low dose Ara-C. Investigations in a marrow grafted patient with relapse

J. Mittermuller; H. J. Kolb; H. H. Gerhartz; W. Wilmanns

Cytotoxic action of low dose Ara-C. Investigations in a marrow grafted patient with relapse

J. Mittermuller, H. J. Kolb, H. H. Gerhartz, W. Wilmanns

Ludwig-Maximilians-Universität München

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Abstract

A 35-year-old woman relapsing from acute myeloid leukemia (AML) after a bone marrow transplantation (BMT) achieved complete remission by low dose Ara-C treatment. Phosphoglucomutase 1 (PGM 1) isoenzyme analysis gave evidence for complete chimerism before relapse, whereas relapsing leukemia was autochtonous. Low dose Ara-C treatment cleared the marrow of leukemic blasts and reestablished normal in vitro growth patterns of myelopoiesis. Disappearance of autochthonous cells and regrowth of transplanted hematopoiesis was shown by PGM 1 isoenzyme analysis. Thus, low dose Ara-C exerted its action - at least in this patient - by cytotoxic mechanisms.

Original language	English
Pages (from-to)	168-171
Number of pages	4
Journal	Onkologie
Volume	8
Issue number	3
State	Published - 1985
Externally published	Yes

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title = "Cytotoxic action of low dose Ara-C. Investigations in a marrow grafted patient with relapse",

abstract = "A 35-year-old woman relapsing from acute myeloid leukemia (AML) after a bone marrow transplantation (BMT) achieved complete remission by low dose Ara-C treatment. Phosphoglucomutase 1 (PGM 1) isoenzyme analysis gave evidence for complete chimerism before relapse, whereas relapsing leukemia was autochtonous. Low dose Ara-C treatment cleared the marrow of leukemic blasts and reestablished normal in vitro growth patterns of myelopoiesis. Disappearance of autochthonous cells and regrowth of transplanted hematopoiesis was shown by PGM 1 isoenzyme analysis. Thus, low dose Ara-C exerted its action - at least in this patient - by cytotoxic mechanisms.",

author = "J. Mittermuller and Kolb, {H. J.} and Gerhartz, {H. H.} and W. Wilmanns",

year = "1985",

language = "English",

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T1 - Cytotoxic action of low dose Ara-C. Investigations in a marrow grafted patient with relapse

AU - Mittermuller, J.

AU - Kolb, H. J.

AU - Gerhartz, H. H.

AU - Wilmanns, W.

PY - 1985

Y1 - 1985

N2 - A 35-year-old woman relapsing from acute myeloid leukemia (AML) after a bone marrow transplantation (BMT) achieved complete remission by low dose Ara-C treatment. Phosphoglucomutase 1 (PGM 1) isoenzyme analysis gave evidence for complete chimerism before relapse, whereas relapsing leukemia was autochtonous. Low dose Ara-C treatment cleared the marrow of leukemic blasts and reestablished normal in vitro growth patterns of myelopoiesis. Disappearance of autochthonous cells and regrowth of transplanted hematopoiesis was shown by PGM 1 isoenzyme analysis. Thus, low dose Ara-C exerted its action - at least in this patient - by cytotoxic mechanisms.

AB - A 35-year-old woman relapsing from acute myeloid leukemia (AML) after a bone marrow transplantation (BMT) achieved complete remission by low dose Ara-C treatment. Phosphoglucomutase 1 (PGM 1) isoenzyme analysis gave evidence for complete chimerism before relapse, whereas relapsing leukemia was autochtonous. Low dose Ara-C treatment cleared the marrow of leukemic blasts and reestablished normal in vitro growth patterns of myelopoiesis. Disappearance of autochthonous cells and regrowth of transplanted hematopoiesis was shown by PGM 1 isoenzyme analysis. Thus, low dose Ara-C exerted its action - at least in this patient - by cytotoxic mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=0022256429&partnerID=8YFLogxK

M3 - Article

C2 - 3160990

AN - SCOPUS:0022256429

SN - 0378-584X

VL - 8

SP - 168

EP - 171

JO - Onkologie

JF - Onkologie

IS - 3

ER -

Cytotoxic action of low dose Ara-C. Investigations in a marrow grafted patient with relapse

Abstract

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