Cytotoxic action of low dose Ara-C. Investigations in a marrow grafted patient with relapse

J. Mittermuller, H. J. Kolb, H. H. Gerhartz, W. Wilmanns

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1 Scopus citations

Abstract

A 35-year-old woman relapsing from acute myeloid leukemia (AML) after a bone marrow transplantation (BMT) achieved complete remission by low dose Ara-C treatment. Phosphoglucomutase 1 (PGM 1) isoenzyme analysis gave evidence for complete chimerism before relapse, whereas relapsing leukemia was autochtonous. Low dose Ara-C treatment cleared the marrow of leukemic blasts and reestablished normal in vitro growth patterns of myelopoiesis. Disappearance of autochthonous cells and regrowth of transplanted hematopoiesis was shown by PGM 1 isoenzyme analysis. Thus, low dose Ara-C exerted its action - at least in this patient - by cytotoxic mechanisms.

Original languageEnglish
Pages (from-to)168-171
Number of pages4
JournalOnkologie
Volume8
Issue number3
StatePublished - 1985
Externally publishedYes

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