Cytosolic Hsp70 as a biomarker to predict clinical outcome in patients with glioblastoma

Friederike Lämmer; Claire Delbridge; Silvia Würstle; Frauke Neff; Bernhard Meyer; Jürgen Schlegel; Kerstin A. Kessel; Thomas E. Schmid; Daniela Schilling; Stephanie E. Combs

doi:10.1371/journal.pone.0221502

Cytosolic Hsp70 as a biomarker to predict clinical outcome in patients with glioblastoma

Friederike Lämmer, Claire Delbridge, Silvia Würstle, Frauke Neff, Bernhard Meyer, Jürgen Schlegel, Kerstin A. Kessel, Thomas E. Schmid, Daniela Schilling, Stephanie E. Combs

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Introduction The major stress-inducible heat shock protein 70 (Hsp70) is induced after different stress stimuli. In tumors, elevated intracellular Hsp70 levels were associated on the one hand with radio- and chemotherapy resistance and on the other hand with a favorable outcome for patients. This study was undertaken to investigate cytosolic Hsp70 (cHsp70) as a potential biomarker for progression free (PFS) and overall survival (OS) in patients with primary glioblastomas (GBM). Methods The cHsp70 expression in tumor tissue of 60 patients diagnosed with primary GBM was analyzed by immunohistochemistry. The cHsp70 expression was correlated to the PFS and OS of the patients. Results A high cHsp70 expression was associated with a prolonged PFS (hazard ratio = 0.374, p = 0.001) and OS (hazard ratio = 0.416, p = 0.014) in GBM patients treated according to the standard Stupp protocol with surgery, radiotherapy and temozolomide. Conclusions These data suggest that the intracellular Hsp70 expression might serve as a prognostic marker in patients with primary GBM.

Original language	English
Article number	e0221502
Journal	PLoS ONE
Volume	14
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0221502
State	Published - 1 Aug 2019
Externally published	Yes

Access to Document

10.1371/journal.pone.0221502

Cite this

@article{c0651e3e1eb74af5b9c56a9c521ae5cf,

title = "Cytosolic Hsp70 as a biomarker to predict clinical outcome in patients with glioblastoma",

abstract = "Introduction The major stress-inducible heat shock protein 70 (Hsp70) is induced after different stress stimuli. In tumors, elevated intracellular Hsp70 levels were associated on the one hand with radio- and chemotherapy resistance and on the other hand with a favorable outcome for patients. This study was undertaken to investigate cytosolic Hsp70 (cHsp70) as a potential biomarker for progression free (PFS) and overall survival (OS) in patients with primary glioblastomas (GBM). Methods The cHsp70 expression in tumor tissue of 60 patients diagnosed with primary GBM was analyzed by immunohistochemistry. The cHsp70 expression was correlated to the PFS and OS of the patients. Results A high cHsp70 expression was associated with a prolonged PFS (hazard ratio = 0.374, p = 0.001) and OS (hazard ratio = 0.416, p = 0.014) in GBM patients treated according to the standard Stupp protocol with surgery, radiotherapy and temozolomide. Conclusions These data suggest that the intracellular Hsp70 expression might serve as a prognostic marker in patients with primary GBM.",

author = "Friederike L{\"a}mmer and Claire Delbridge and Silvia W{\"u}rstle and Frauke Neff and Bernhard Meyer and J{\"u}rgen Schlegel and Kessel, {Kerstin A.} and Schmid, {Thomas E.} and Daniela Schilling and Combs, {Stephanie E.}",

note = "Publisher Copyright: {\textcopyright} 2019 L{\"a}mmer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2019",

month = aug,

day = "1",

doi = "10.1371/journal.pone.0221502",

language = "English",

volume = "14",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "8",

}

TY - JOUR

T1 - Cytosolic Hsp70 as a biomarker to predict clinical outcome in patients with glioblastoma

AU - Lämmer, Friederike

AU - Delbridge, Claire

AU - Würstle, Silvia

AU - Neff, Frauke

AU - Meyer, Bernhard

AU - Schlegel, Jürgen

AU - Kessel, Kerstin A.

AU - Schmid, Thomas E.

AU - Schilling, Daniela

AU - Combs, Stephanie E.

N1 - Publisher Copyright: © 2019 Lämmer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Introduction The major stress-inducible heat shock protein 70 (Hsp70) is induced after different stress stimuli. In tumors, elevated intracellular Hsp70 levels were associated on the one hand with radio- and chemotherapy resistance and on the other hand with a favorable outcome for patients. This study was undertaken to investigate cytosolic Hsp70 (cHsp70) as a potential biomarker for progression free (PFS) and overall survival (OS) in patients with primary glioblastomas (GBM). Methods The cHsp70 expression in tumor tissue of 60 patients diagnosed with primary GBM was analyzed by immunohistochemistry. The cHsp70 expression was correlated to the PFS and OS of the patients. Results A high cHsp70 expression was associated with a prolonged PFS (hazard ratio = 0.374, p = 0.001) and OS (hazard ratio = 0.416, p = 0.014) in GBM patients treated according to the standard Stupp protocol with surgery, radiotherapy and temozolomide. Conclusions These data suggest that the intracellular Hsp70 expression might serve as a prognostic marker in patients with primary GBM.

AB - Introduction The major stress-inducible heat shock protein 70 (Hsp70) is induced after different stress stimuli. In tumors, elevated intracellular Hsp70 levels were associated on the one hand with radio- and chemotherapy resistance and on the other hand with a favorable outcome for patients. This study was undertaken to investigate cytosolic Hsp70 (cHsp70) as a potential biomarker for progression free (PFS) and overall survival (OS) in patients with primary glioblastomas (GBM). Methods The cHsp70 expression in tumor tissue of 60 patients diagnosed with primary GBM was analyzed by immunohistochemistry. The cHsp70 expression was correlated to the PFS and OS of the patients. Results A high cHsp70 expression was associated with a prolonged PFS (hazard ratio = 0.374, p = 0.001) and OS (hazard ratio = 0.416, p = 0.014) in GBM patients treated according to the standard Stupp protocol with surgery, radiotherapy and temozolomide. Conclusions These data suggest that the intracellular Hsp70 expression might serve as a prognostic marker in patients with primary GBM.

UR - http://www.scopus.com/inward/record.url?scp=85071031097&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0221502

DO - 10.1371/journal.pone.0221502

M3 - Article

C2 - 31430337

AN - SCOPUS:85071031097

SN - 1932-6203

VL - 14

JO - PLoS ONE

JF - PLoS ONE

IS - 8

M1 - e0221502

ER -

Cytosolic Hsp70 as a biomarker to predict clinical outcome in patients with glioblastoma

Abstract

Access to Document

Other files and links

Fingerprint

Cite this