Cytokine therapy of neoplastic and inflammatory disease

W. E. Aulitzky, C. Huber, C. Peschel

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Cytokines have been widely tested in clinical trials during recent years and beneficial responses have been observed in a variety of malignant, infectious and autoimmune diseases. Interferon-α induces remissions in patients with certain hematological malignancies such as hairy cell leukemia and chronic myelogenous leukemia. A proportion of patients with chronic viral hepatitis is cured upon application of interferon-α. Treatment with interferon-γ reduces the number of infections in patients with chronic granulomatous disease. In addition, several chronic infections with intracellular pathogens also respond to treatment with this cytokine. With the exception of some patients with renal cell carcinoma and malignant melanoma, solid tumors are largely resistant to administration of these cytokines. Cytokine treatment has changed the outlook for a small group of patients with selected chronic diseases. However, clinical experience with cytokines is still limited and only interferons have been tested for treatment of a variety of diseases. Thus, it seems reasonable to expect that more cytokine-responsive diseases might be identified by continued research efforts.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalInternational Archives of Allergy and Immunology
Issue number3
StatePublished - 1993
Externally publishedYes


  • Chronic myelogenous leukemia
  • Cytokines
  • Interferon
  • Interleukin 2
  • Renal cell carcinoma


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