(+)-Cyanidanol-3 changes functional properties of collagen

B. F. Pontz; T. Krieg; P. K. Müller

doi:10.1016/0006-2952(82)90579-2

(+)-Cyanidanol-3 changes functional properties of collagen

B. F. Pontz, T. Krieg, P. K. Müller

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

About 6-7 (+)-cyanidanol-3 molecules are bound per collagen α-chain. The (+)-cyanidanol-3 treated collagen contains an increased number of pepsin-resistant cross-links, is less susceptible to attack by mammalian collagenase, has a higher shrinkage temp and forms unstructured aggregates. Cell and organ culture studies show that these biological systems produce less protein and collagen in the presence of (+)-cyanidanol-3 and that the newly synthesized collagen is less soluble.

Original language	English
Pages (from-to)	3581-3589
Number of pages	9
Journal	Biochemical Pharmacology
Volume	31
Issue number	22
DOIs	https://doi.org/10.1016/0006-2952(82)90579-2
State	Published - 15 Nov 1982
Externally published	Yes

Access to Document

10.1016/0006-2952(82)90579-2

Cite this

@article{b779dd32f4154e3aa8160aec2adb04c8,

title = "(+)-Cyanidanol-3 changes functional properties of collagen",

abstract = "About 6-7 (+)-cyanidanol-3 molecules are bound per collagen α-chain. The (+)-cyanidanol-3 treated collagen contains an increased number of pepsin-resistant cross-links, is less susceptible to attack by mammalian collagenase, has a higher shrinkage temp and forms unstructured aggregates. Cell and organ culture studies show that these biological systems produce less protein and collagen in the presence of (+)-cyanidanol-3 and that the newly synthesized collagen is less soluble.",

author = "Pontz, {B. F.} and T. Krieg and M{\"u}ller, {P. K.}",

note = "Funding Information: Acknowledgements--The study was supported by the VW-Stifung, project {"}Skeletal dysplasias{"}. The excellent technical assistance of H. Messer is gratefully acknowledged.",

year = "1982",

month = nov,

day = "15",

doi = "10.1016/0006-2952(82)90579-2",

language = "English",

volume = "31",

pages = "3581--3589",

journal = "Biochemical Pharmacology",

issn = "0006-2952",

publisher = "Elsevier Inc.",

number = "22",

}

TY - JOUR

T1 - (+)-Cyanidanol-3 changes functional properties of collagen

AU - Pontz, B. F.

AU - Krieg, T.

AU - Müller, P. K.

N1 - Funding Information: Acknowledgements--The study was supported by the VW-Stifung, project "Skeletal dysplasias". The excellent technical assistance of H. Messer is gratefully acknowledged.

PY - 1982/11/15

Y1 - 1982/11/15

N2 - About 6-7 (+)-cyanidanol-3 molecules are bound per collagen α-chain. The (+)-cyanidanol-3 treated collagen contains an increased number of pepsin-resistant cross-links, is less susceptible to attack by mammalian collagenase, has a higher shrinkage temp and forms unstructured aggregates. Cell and organ culture studies show that these biological systems produce less protein and collagen in the presence of (+)-cyanidanol-3 and that the newly synthesized collagen is less soluble.

AB - About 6-7 (+)-cyanidanol-3 molecules are bound per collagen α-chain. The (+)-cyanidanol-3 treated collagen contains an increased number of pepsin-resistant cross-links, is less susceptible to attack by mammalian collagenase, has a higher shrinkage temp and forms unstructured aggregates. Cell and organ culture studies show that these biological systems produce less protein and collagen in the presence of (+)-cyanidanol-3 and that the newly synthesized collagen is less soluble.

UR - http://www.scopus.com/inward/record.url?scp=0020381629&partnerID=8YFLogxK

U2 - 10.1016/0006-2952(82)90579-2

DO - 10.1016/0006-2952(82)90579-2

M3 - Article

C2 - 6295404

AN - SCOPUS:0020381629

SN - 0006-2952

VL - 31

SP - 3581

EP - 3589

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 22

ER -

(+)-Cyanidanol-3 changes functional properties of collagen

Abstract

Access to Document

Other files and links

Fingerprint

Cite this