TY - JOUR
T1 - Cutaneous Barriers and Skin Immunity
T2 - Differentiating A Connected Network
AU - Eyerich, Stefanie
AU - Eyerich, Kilian
AU - Traidl-Hoffmann, Claudia
AU - Biedermann, Tilo
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/4
Y1 - 2018/4
N2 - The skin is the outermost barrier of the organism that ensures protection from external harm. Lately, our view of the skin has evolved from an inert mechanical barrier to an active organ that can sense danger signals and mount perfectly adapted defense measures in response to invading pathogens. This Review highlights the different levels of the cutaneous barrier (the microbiome, chemical, physical, and immune barriers), their characteristics, and functional, highly interconnected network of cells and mediators that allow balanced defense measures to protect the body and maintain barrier integrity.
AB - The skin is the outermost barrier of the organism that ensures protection from external harm. Lately, our view of the skin has evolved from an inert mechanical barrier to an active organ that can sense danger signals and mount perfectly adapted defense measures in response to invading pathogens. This Review highlights the different levels of the cutaneous barrier (the microbiome, chemical, physical, and immune barriers), their characteristics, and functional, highly interconnected network of cells and mediators that allow balanced defense measures to protect the body and maintain barrier integrity.
UR - http://www.scopus.com/inward/record.url?scp=85043765940&partnerID=8YFLogxK
U2 - 10.1016/j.it.2018.02.004
DO - 10.1016/j.it.2018.02.004
M3 - Review article
C2 - 29551468
AN - SCOPUS:85043765940
SN - 1471-4906
VL - 39
SP - 315
EP - 327
JO - Trends in Immunology
JF - Trends in Immunology
IS - 4
ER -