Abstract
Reinfusion of the coronary veins has gained attention for therapeutic approaches which target drugs, genes or cells to ischemic myocardium. Besides anatomy of the coronary venous system, the pressure flow relationship during retroinfusion and the efficacy of pressure-regulated selective retroinfusion for targeted delivery of drugs is reported. Moreover, we describe adenoviral and liposomal gene transfer in ischemic and non-ischemic myocardium, outline studies in chronic ischemic preclinical models treated by retroinfusion for cell-based regenerative therapy of the diseased myocardium.
| Original language | English |
|---|---|
| Pages (from-to) | 373-381 |
| Number of pages | 9 |
| Journal | Basic Research in Cardiology |
| Volume | 99 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 2004 |
| Externally published | Yes |
Keywords
- Angiogenesis
- Arteriogenesis
- Cell based therapy
- Ischemia-reperfusion
- Pressure regulation
- Selective retroinfusion