Current concepts and applications of coronary venous retroinfusion

Peter Boekstegers, Christian Kupatt

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Reinfusion of the coronary veins has gained attention for therapeutic approaches which target drugs, genes or cells to ischemic myocardium. Besides anatomy of the coronary venous system, the pressure flow relationship during retroinfusion and the efficacy of pressure-regulated selective retroinfusion for targeted delivery of drugs is reported. Moreover, we describe adenoviral and liposomal gene transfer in ischemic and non-ischemic myocardium, outline studies in chronic ischemic preclinical models treated by retroinfusion for cell-based regenerative therapy of the diseased myocardium.

Original languageEnglish
Pages (from-to)373-381
Number of pages9
JournalBasic Research in Cardiology
Volume99
Issue number6
DOIs
StatePublished - Nov 2004
Externally publishedYes

Keywords

  • Angiogenesis
  • Arteriogenesis
  • Cell based therapy
  • Ischemia-reperfusion
  • Pressure regulation
  • Selective retroinfusion

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