TY - JOUR
T1 - CT-guided biopsy of bone and soft-tissue lesions
T2 - Role of on-site immediate cytologic evaluation
AU - Virayavanich, Warapat
AU - Ringler, Michael D.
AU - Chin, Cynthia T.
AU - Baum, Thomas
AU - Giaconi, Joseph C.
AU - O'Donnell, Richard J.
AU - Horvai, Andrew E.
AU - Jones, Kirk D.
AU - Link, Thomas M.
PY - 2011/7
Y1 - 2011/7
N2 - Purpose: To assess the impact of on-site immediate cytologic assessment (ICA) on the diagnostic success rate of computed tomography (CT)guided percutaneous needle biopsy (PNB) of musculoskeletal lesions and the long-term outcome in inconclusive PNB findings. Materials and Methods: A total of 299 CT-guided PNBs of musculoskeletal lesions performed between January 1997 and December 2009 were retrospectively reviewed. The lesions were categorized by their morphology, location, and size, and by biopsy type. The diagnostic success rates, impact of ICA, and outcome in inconclusive PNBs were studied, with final histopathologic findings and/or clinical follow-up as a reference. Results: The overall diagnostic success rate of PNBs was 72.9% (218 of 299). The success rate increased with larger lesions (> 2 cm to 4 cm; P = .009). Biopsies performed with ICA had a higher success rate (77.0% vs 63.3%; P = .015). PNBs had inconclusive results in 109 of 299 cases (36.5%). In 66 of these, repeat open biopsy or clinical follow-up demonstrated 19 malignant/aggressive lesions (28.8%) and 47 benign/nonaggressive lesions (71.2%). Conclusions: CT-guided PNB had a satisfactory success rate, which significantly increased when performed with ICA. Inconclusive results in PNB were most frequently associated with benign findings during further workup.
AB - Purpose: To assess the impact of on-site immediate cytologic assessment (ICA) on the diagnostic success rate of computed tomography (CT)guided percutaneous needle biopsy (PNB) of musculoskeletal lesions and the long-term outcome in inconclusive PNB findings. Materials and Methods: A total of 299 CT-guided PNBs of musculoskeletal lesions performed between January 1997 and December 2009 were retrospectively reviewed. The lesions were categorized by their morphology, location, and size, and by biopsy type. The diagnostic success rates, impact of ICA, and outcome in inconclusive PNBs were studied, with final histopathologic findings and/or clinical follow-up as a reference. Results: The overall diagnostic success rate of PNBs was 72.9% (218 of 299). The success rate increased with larger lesions (> 2 cm to 4 cm; P = .009). Biopsies performed with ICA had a higher success rate (77.0% vs 63.3%; P = .015). PNBs had inconclusive results in 109 of 299 cases (36.5%). In 66 of these, repeat open biopsy or clinical follow-up demonstrated 19 malignant/aggressive lesions (28.8%) and 47 benign/nonaggressive lesions (71.2%). Conclusions: CT-guided PNB had a satisfactory success rate, which significantly increased when performed with ICA. Inconclusive results in PNB were most frequently associated with benign findings during further workup.
KW - CNB
KW - FNA
KW - ICA
KW - PNB
KW - core needle biopsy
KW - fine-needle aspiration
KW - immediate cytologic assessment
KW - percutaneous needle biopsy
UR - http://www.scopus.com/inward/record.url?scp=79959760510&partnerID=8YFLogxK
U2 - 10.1016/j.jvir.2011.03.019
DO - 10.1016/j.jvir.2011.03.019
M3 - Article
C2 - 21570872
AN - SCOPUS:79959760510
SN - 1051-0443
VL - 22
SP - 1024
EP - 1030
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 7
ER -