CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume

Emrah Düzel; David Berron; Hartmut Schütze; Arturo Cardenas-Blanco; Coraline Metzger; Matthew Betts; Gabriel Ziegler; Yi Chen; Laura Dobisch; Daniel Bittner; Wenzel Glanz; Martin Reuter; Annika Spottke; Janna Rudolph; Frederic Brosseron; Katharina Buerger; Daniel Janowitz; Klaus Fliessbach; Michael Heneka; Christoph Laske; Martina Buchmann; Peter Nestor; Oliver Peters; Dominik Diesing; Siyao Li; Josef Priller; Eike Jakob Spruth; Slawek Altenstein; Alfredo Ramirez; Anja Schneider; Barbara Kofler; Oliver Speck; Stefan Teipel; Ingo Kilimann; Martin Dyrba; Jens Wiltfang; Claudia Bartels; Steffen Wolfsgruber; Michael Wagner; Frank Jessen

doi:10.1016/j.dadm.2018.10.003

CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume

Emrah Düzel
, David Berron
, Hartmut Schütze
, Arturo Cardenas-Blanco
, Coraline Metzger
, Matthew Betts
, Gabriel Ziegler
, Yi Chen
, Laura Dobisch
, Daniel Bittner
, Wenzel Glanz
, Martin Reuter
, Annika Spottke
, Janna Rudolph
, Frederic Brosseron
, Katharina Buerger
, Daniel Janowitz
, Klaus Fliessbach
, Michael Heneka
, Christoph Laske

Martina Buchmann, Peter Nestor, Oliver Peters, Dominik Diesing, Siyao Li, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Alfredo Ramirez, Anja Schneider, Barbara Kofler, Oliver Speck, Stefan Teipel, Ingo Kilimann, Martin Dyrba, Jens Wiltfang, Claudia Bartels, Steffen Wolfsgruber, Michael Wagner, Frank Jessen

Otto-von-Guericke University
German Center for Neurodegenerative Diseases (DZNE)
University College London
Magdeburg University Hospital
University of Bonn
University of Bonn and University Hospital Bonn
Ludwig-Maximilians-Universität München
University Clinic Tuebingen
Charite Universitätsmedizin Berlin
Department of Psychiatry and Psychotherapy
University of Cologne
Department of Biomagnetical Resonance
Rostock University Medical Center
University Medical Center

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Introduction: We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age. Methods: We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment). We assessed the correlation between CSF biomarkers and whole-brain functional magnetic resonance imaging novelty responses to scene images. Results: Total tau levels were specifically and negatively associated with novelty responses in the right amygdala and right hippocampus. Mediation analyses showed no evidence that these associations were dependent on the volume of hippocampus/amygdala. No relationship was found between phosphorylated-tau or Aβ₄₂ levels and novelty responses. Discussion: Our data show that CSF levels of total tau are associated with anatomically specific reductions in novelty processing, which cannot be fully explained by atrophy.

Original language	English
Pages (from-to)	782-790
Number of pages	9
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	10
DOIs	https://doi.org/10.1016/j.dadm.2018.10.003
State	Published - 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alzheimer's disease (AD)
Apolipoprotein E (APOE)
Aβ
Cerebrospinal fluid (CSF)
Longitudinal
Magnetic resonance imaging (MRI)
Mild cognitive impairment (MCI)
Positron emission tomography (PET)
Subjective cognitive decline (SCD)
Tau

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10.1016/j.dadm.2018.10.003

Cite this

Düzel, E., Berron, D., Schütze, H., Cardenas-Blanco, A., Metzger, C., Betts, M., Ziegler, G., Chen, Y., Dobisch, L., Bittner, D., Glanz, W., Reuter, M., Spottke, A., Rudolph, J., Brosseron, F., Buerger, K., Janowitz, D., Fliessbach, K., Heneka, M., ... Jessen, F. (2018). CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 10, 782-790. https://doi.org/10.1016/j.dadm.2018.10.003

@article{c564f04f891b4f1eb7d74518e3ae5385,

title = "CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume",

abstract = "Introduction: We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age. Methods: We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment). We assessed the correlation between CSF biomarkers and whole-brain functional magnetic resonance imaging novelty responses to scene images. Results: Total tau levels were specifically and negatively associated with novelty responses in the right amygdala and right hippocampus. Mediation analyses showed no evidence that these associations were dependent on the volume of hippocampus/amygdala. No relationship was found between phosphorylated-tau or Aβ42 levels and novelty responses. Discussion: Our data show that CSF levels of total tau are associated with anatomically specific reductions in novelty processing, which cannot be fully explained by atrophy.",

keywords = "Alzheimer's disease (AD), Apolipoprotein E (APOE), Aβ, Cerebrospinal fluid (CSF), Longitudinal, Magnetic resonance imaging (MRI), Mild cognitive impairment (MCI), Positron emission tomography (PET), Subjective cognitive decline (SCD), Tau",

author = "Emrah D{\"u}zel and David Berron and Hartmut Sch{\"u}tze and Arturo Cardenas-Blanco and Coraline Metzger and Matthew Betts and Gabriel Ziegler and Yi Chen and Laura Dobisch and Daniel Bittner and Wenzel Glanz and Martin Reuter and Annika Spottke and Janna Rudolph and Frederic Brosseron and Katharina Buerger and Daniel Janowitz and Klaus Fliessbach and Michael Heneka and Christoph Laske and Martina Buchmann and Peter Nestor and Oliver Peters and Dominik Diesing and Siyao Li and Josef Priller and Spruth, \{Eike Jakob\} and Slawek Altenstein and Alfredo Ramirez and Anja Schneider and Barbara Kofler and Oliver Speck and Stefan Teipel and Ingo Kilimann and Martin Dyrba and Jens Wiltfang and Claudia Bartels and Steffen Wolfsgruber and Michael Wagner and Frank Jessen",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2018",

doi = "10.1016/j.dadm.2018.10.003",

language = "English",

volume = "10",

pages = "782--790",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

issn = "2352-8729",

publisher = "John Wiley and Sons Inc.",

}

Düzel, E, Berron, D, Schütze, H, Cardenas-Blanco, A, Metzger, C, Betts, M, Ziegler, G, Chen, Y, Dobisch, L, Bittner, D, Glanz, W, Reuter, M, Spottke, A, Rudolph, J, Brosseron, F, Buerger, K, Janowitz, D, Fliessbach, K, Heneka, M, Laske, C, Buchmann, M, Nestor, P, Peters, O, Diesing, D, Li, S, Priller, J, Spruth, EJ, Altenstein, S, Ramirez, A, Schneider, A, Kofler, B, Speck, O, Teipel, S, Kilimann, I, Dyrba, M, Wiltfang, J, Bartels, C, Wolfsgruber, S, Wagner, M & Jessen, F 2018, 'CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 10, pp. 782-790. https://doi.org/10.1016/j.dadm.2018.10.003

TY - JOUR

T1 - CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume

AU - Düzel, Emrah

AU - Berron, David

AU - Schütze, Hartmut

AU - Cardenas-Blanco, Arturo

AU - Metzger, Coraline

AU - Betts, Matthew

AU - Ziegler, Gabriel

AU - Chen, Yi

AU - Dobisch, Laura

AU - Bittner, Daniel

AU - Glanz, Wenzel

AU - Reuter, Martin

AU - Spottke, Annika

AU - Rudolph, Janna

AU - Brosseron, Frederic

AU - Buerger, Katharina

AU - Janowitz, Daniel

AU - Fliessbach, Klaus

AU - Heneka, Michael

AU - Laske, Christoph

AU - Buchmann, Martina

AU - Nestor, Peter

AU - Peters, Oliver

AU - Diesing, Dominik

AU - Li, Siyao

AU - Priller, Josef

AU - Spruth, Eike Jakob

AU - Altenstein, Slawek

AU - Ramirez, Alfredo

AU - Schneider, Anja

AU - Kofler, Barbara

AU - Speck, Oliver

AU - Teipel, Stefan

AU - Kilimann, Ingo

AU - Dyrba, Martin

AU - Wiltfang, Jens

AU - Bartels, Claudia

AU - Wolfsgruber, Steffen

AU - Wagner, Michael

AU - Jessen, Frank

PY - 2018

Y1 - 2018

N2 - Introduction: We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age. Methods: We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment). We assessed the correlation between CSF biomarkers and whole-brain functional magnetic resonance imaging novelty responses to scene images. Results: Total tau levels were specifically and negatively associated with novelty responses in the right amygdala and right hippocampus. Mediation analyses showed no evidence that these associations were dependent on the volume of hippocampus/amygdala. No relationship was found between phosphorylated-tau or Aβ42 levels and novelty responses. Discussion: Our data show that CSF levels of total tau are associated with anatomically specific reductions in novelty processing, which cannot be fully explained by atrophy.

AB - Introduction: We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age. Methods: We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment). We assessed the correlation between CSF biomarkers and whole-brain functional magnetic resonance imaging novelty responses to scene images. Results: Total tau levels were specifically and negatively associated with novelty responses in the right amygdala and right hippocampus. Mediation analyses showed no evidence that these associations were dependent on the volume of hippocampus/amygdala. No relationship was found between phosphorylated-tau or Aβ42 levels and novelty responses. Discussion: Our data show that CSF levels of total tau are associated with anatomically specific reductions in novelty processing, which cannot be fully explained by atrophy.

KW - Alzheimer's disease (AD)

KW - Apolipoprotein E (APOE)

KW - Aβ

KW - Cerebrospinal fluid (CSF)

KW - Longitudinal

KW - Magnetic resonance imaging (MRI)

KW - Mild cognitive impairment (MCI)

KW - Positron emission tomography (PET)

KW - Subjective cognitive decline (SCD)

KW - Tau

UR - https://www.scopus.com/pages/publications/85057812601

U2 - 10.1016/j.dadm.2018.10.003

DO - 10.1016/j.dadm.2018.10.003

M3 - Article

AN - SCOPUS:85057812601

SN - 2352-8729

VL - 10

SP - 782

EP - 790

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

ER -

CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume

Abstract

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Keywords

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