CSF protein concentration shows no correlation with brain volume measures

Alexander Wuschek; Sophia Grahl; Viola Pongratz; Thomas Korn; Jan Kirschke; Claus Zimmer; Bernhard Hemmer; Mark Mühlau

doi:10.3389/fneur.2019.00463

CSF protein concentration shows no correlation with brain volume measures

Alexander Wuschek, Sophia Grahl, Viola Pongratz, Thomas Korn, Jan Kirschke, Claus Zimmer, Bernhard Hemmer, Mark Mühlau

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Abstract

Background: CSF protein concentrations vary greatly among individuals. Accounting for brain volume may lower the variance and increase the diagnostic value of CSF protein concentrations. Objective: To determine the relation between CSF protein concentrations and brain volume. Methods: Brain volumes (total intracranial, gray matter, white matter volumes) derived from brain MRI and CSF protein concentrations (total protein, albumin, albumin CSF/serum ratio) of 29 control patients and 497 patients with clinically isolated syndrome or multiple sclerosis were studied. Finding: We found significant positive correlations of CSF protein concentrations with intracranial, gray matter, and white matter volumes. None of the correlations remained significant after correction for age and sex. Conclusion: Accounting for brain volume derived from brain MRI is unlikely to improve the diagnostic value of protein concentrations in CSF.

Original language	English
Article number	463
Journal	Frontiers in Neurology
Volume	10
Issue number	MAY
DOIs	https://doi.org/10.3389/fneur.2019.00463
State	Published - 2019

Keywords

Albumin
Brain volume
CSF
MRI
Protein

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title = "CSF protein concentration shows no correlation with brain volume measures",

abstract = "Background: CSF protein concentrations vary greatly among individuals. Accounting for brain volume may lower the variance and increase the diagnostic value of CSF protein concentrations. Objective: To determine the relation between CSF protein concentrations and brain volume. Methods: Brain volumes (total intracranial, gray matter, white matter volumes) derived from brain MRI and CSF protein concentrations (total protein, albumin, albumin CSF/serum ratio) of 29 control patients and 497 patients with clinically isolated syndrome or multiple sclerosis were studied. Finding: We found significant positive correlations of CSF protein concentrations with intracranial, gray matter, and white matter volumes. None of the correlations remained significant after correction for age and sex. Conclusion: Accounting for brain volume derived from brain MRI is unlikely to improve the diagnostic value of protein concentrations in CSF.",

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T1 - CSF protein concentration shows no correlation with brain volume measures

AU - Wuschek, Alexander

AU - Grahl, Sophia

AU - Pongratz, Viola

AU - Korn, Thomas

AU - Kirschke, Jan

AU - Zimmer, Claus

AU - Hemmer, Bernhard

AU - Mühlau, Mark

PY - 2019

Y1 - 2019

N2 - Background: CSF protein concentrations vary greatly among individuals. Accounting for brain volume may lower the variance and increase the diagnostic value of CSF protein concentrations. Objective: To determine the relation between CSF protein concentrations and brain volume. Methods: Brain volumes (total intracranial, gray matter, white matter volumes) derived from brain MRI and CSF protein concentrations (total protein, albumin, albumin CSF/serum ratio) of 29 control patients and 497 patients with clinically isolated syndrome or multiple sclerosis were studied. Finding: We found significant positive correlations of CSF protein concentrations with intracranial, gray matter, and white matter volumes. None of the correlations remained significant after correction for age and sex. Conclusion: Accounting for brain volume derived from brain MRI is unlikely to improve the diagnostic value of protein concentrations in CSF.

AB - Background: CSF protein concentrations vary greatly among individuals. Accounting for brain volume may lower the variance and increase the diagnostic value of CSF protein concentrations. Objective: To determine the relation between CSF protein concentrations and brain volume. Methods: Brain volumes (total intracranial, gray matter, white matter volumes) derived from brain MRI and CSF protein concentrations (total protein, albumin, albumin CSF/serum ratio) of 29 control patients and 497 patients with clinically isolated syndrome or multiple sclerosis were studied. Finding: We found significant positive correlations of CSF protein concentrations with intracranial, gray matter, and white matter volumes. None of the correlations remained significant after correction for age and sex. Conclusion: Accounting for brain volume derived from brain MRI is unlikely to improve the diagnostic value of protein concentrations in CSF.

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CSF protein concentration shows no correlation with brain volume measures

Abstract

Keywords

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