TY - JOUR
T1 - Cryoballoon in AF ablation
T2 - Impact of PV ovality on AF recurrence
AU - Schmidt, Martin
AU - Dorwarth, Uwe
AU - Straube, Florian
AU - Daccarett, Marcos
AU - Rieber, Johannes
AU - Wankerl, Michael
AU - Krieg, Jürgen
AU - Leber, Alexander W.
AU - Ebersberger, Ullrich
AU - Huber, Armin
AU - Rummeny, Ernst
AU - Hoffmann, Ellen
PY - 2013/7/15
Y1 - 2013/7/15
N2 - Introduction: Complete occlusion of the pulmonary veins (PV) is crucial for successful PV isolation. While two different sizes of cryoballoons (23 and 28 mm) are available, complete occlusion is not always achieved in any given PV. We investigated the role of PV ostial anatomy during cryoballoon PV occlusion grading and atrial fibrillation (AF) recurrence rate. Methods: PV ostial diameter was analyzed in 168 consecutive patients (111 men, 61 ± 10 years, 124 paroxysmal (px) and 44 persistent AF) using cardiac computed tomography (CT) prior to procedure. The ovality index at the PV ostial level was calculated in any given PV. During follow-up, 7-day holter monitors were performed at 1, 3, 6, 9, 12, 18 and 24 months post-ablation. Results: The success rate at 12 ± 6 months follow-up was 69% including a 3-month blanking period (px AF: 66%; persistent AF 77%). The ovality index of the left-sided PVs was significantly larger ("more oval") than that of the right-sided PVs (p < 0.001). An optimized PV occlusion in all individual PVs (complete occlusion, grading 4/4) was achieved during ablation in 49% of patients with AF recurrence and in 73% of patients without AF recurrence (p = 0.004). Patients with AF recurrence had "more oval" left-sided PVs compared to patients free from AF recurrence (LSPV 0.40 ± 0.2 vs. 0.33 ± 0.2; p = 0.04 and LIPV 0.41 ± 0.3 vs. 0.32 ± 0.2; p = 0.03), whereas no significant association was found for right sided PVs. Conclusion: The ostial PV anatomy seems to have an important impact on clinical outcome and should be considered when planning and performing cryoballoon AF ablation procedures.
AB - Introduction: Complete occlusion of the pulmonary veins (PV) is crucial for successful PV isolation. While two different sizes of cryoballoons (23 and 28 mm) are available, complete occlusion is not always achieved in any given PV. We investigated the role of PV ostial anatomy during cryoballoon PV occlusion grading and atrial fibrillation (AF) recurrence rate. Methods: PV ostial diameter was analyzed in 168 consecutive patients (111 men, 61 ± 10 years, 124 paroxysmal (px) and 44 persistent AF) using cardiac computed tomography (CT) prior to procedure. The ovality index at the PV ostial level was calculated in any given PV. During follow-up, 7-day holter monitors were performed at 1, 3, 6, 9, 12, 18 and 24 months post-ablation. Results: The success rate at 12 ± 6 months follow-up was 69% including a 3-month blanking period (px AF: 66%; persistent AF 77%). The ovality index of the left-sided PVs was significantly larger ("more oval") than that of the right-sided PVs (p < 0.001). An optimized PV occlusion in all individual PVs (complete occlusion, grading 4/4) was achieved during ablation in 49% of patients with AF recurrence and in 73% of patients without AF recurrence (p = 0.004). Patients with AF recurrence had "more oval" left-sided PVs compared to patients free from AF recurrence (LSPV 0.40 ± 0.2 vs. 0.33 ± 0.2; p = 0.04 and LIPV 0.41 ± 0.3 vs. 0.32 ± 0.2; p = 0.03), whereas no significant association was found for right sided PVs. Conclusion: The ostial PV anatomy seems to have an important impact on clinical outcome and should be considered when planning and performing cryoballoon AF ablation procedures.
KW - Ablation
KW - Atrial fibrillation
KW - Cryoballoon
KW - Ovality index
KW - Pulmonary vein
UR - https://www.scopus.com/pages/publications/84878595428
U2 - 10.1016/j.ijcard.2011.12.017
DO - 10.1016/j.ijcard.2011.12.017
M3 - Article
C2 - 22206633
AN - SCOPUS:84878595428
SN - 0167-5273
VL - 167
SP - 114
EP - 120
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 1
ER -