Crosslinking proteins modulate the self-organization of driven systems

Volker Schaller; Kurt M. Schmoller; Esra Karaköse; Benjamin Hammerich; Matthias Maier; Andreas R. Bausch

doi:10.1039/c3sm50506e

Crosslinking proteins modulate the self-organization of driven systems

Volker Schaller, Kurt M. Schmoller, Esra Karaköse, Benjamin Hammerich, Matthias Maier, Andreas R. Bausch

Chair of Cellular Biophysics

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The inherent activity of the cellular cytoskeleton is responsible for its unique properties-but at the same time impedes its thorough understanding. It is extremely challenging to predict to what extent the specific properties of its constituents affect the overall dynamic properties. By using high density motility assays, we show that the interplay of only three components-molecular motors, filamentous actin and crosslinking proteins-is sufficient for an extremely broad range of self-organization phenomena. They range from the assembly of large-scale polar structures to contracting networks and crucially depend on the specific properties of the crosslinking proteins.

Original language	English
Pages (from-to)	7229-7233
Number of pages	5
Journal	Soft Matter
Volume	9
Issue number	30
DOIs	https://doi.org/10.1039/c3sm50506e
State	Published - 14 Aug 2013

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AU - Maier, Matthias

AU - Bausch, Andreas R.

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AB - The inherent activity of the cellular cytoskeleton is responsible for its unique properties-but at the same time impedes its thorough understanding. It is extremely challenging to predict to what extent the specific properties of its constituents affect the overall dynamic properties. By using high density motility assays, we show that the interplay of only three components-molecular motors, filamentous actin and crosslinking proteins-is sufficient for an extremely broad range of self-organization phenomena. They range from the assembly of large-scale polar structures to contracting networks and crucially depend on the specific properties of the crosslinking proteins.

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Crosslinking proteins modulate the self-organization of driven systems

Abstract

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