Cross-priming in health and disease

Christian Kurts; Bruce W.S. Robinson; Percy A. Knolle

doi:10.1038/nri2780

Cross-priming in health and disease

Christian Kurts, Bruce W.S. Robinson, Percy A. Knolle

Research output: Contribution to journal › Review article › peer-review

340 Scopus citations

Abstract

Cross-priming is an important mechanism to activate cytotoxic T lymphocytes (CTLs) for immune defence against viruses and tumours. Although it was discovered more than 25 years ago, we have only recently gained insight into the underlying cellular and molecular mechanisms, and we are just beginning to understand its physiological importance in health and disease. Here we summarize current concepts on the cross-talk between the immune cells involved in CTL cross-priming and on its role in antimicrobial and antitumour defence, as well as in immune-mediated diseases.

Original language	English
Pages (from-to)	403-414
Number of pages	12
Journal	Nature Reviews Immunology
Volume	10
Issue number	6
DOIs	https://doi.org/10.1038/nri2780
State	Published - May 2010
Externally published	Yes

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title = "Cross-priming in health and disease",

abstract = "Cross-priming is an important mechanism to activate cytotoxic T lymphocytes (CTLs) for immune defence against viruses and tumours. Although it was discovered more than 25 years ago, we have only recently gained insight into the underlying cellular and molecular mechanisms, and we are just beginning to understand its physiological importance in health and disease. Here we summarize current concepts on the cross-talk between the immune cells involved in CTL cross-priming and on its role in antimicrobial and antitumour defence, as well as in immune-mediated diseases.",

author = "Christian Kurts and Robinson, {Bruce W.S.} and Knolle, {Percy A.}",

note = "Funding Information: The authors thank W. Kolanus (LIMES Institute Bonn), J. Yewdell (NIH), M. von Herrath (LIAI) and R. Slattery (Monash University Melbourne) for comments and discussions. We apologize to all colleagues whose work could not be cited owing to space restrictions. The authors are supported by the German Research foundation (DFG Sonderforschungsbereiche 704, 670 and 645, Transregio 57, Klinische Forschergruppe 228), the German Academic Exchange service (DAAD) and the Group of Eight, Australia.",

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Cross-priming in health and disease

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