Cross-diffusion induced patterns for a single-step enzymatic reaction

Giovanni Giunta, Hamid Seyed-Allaei, Ulrich Gerland

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Several different enzymes display an apparent diffusion coefficient that increases with the concentration of their substrate. Moreover, their motion becomes directed in substrate gradients. Currently, there are several competing models for these transport dynamics. Here, we use mathematical modeling and numerical simulations to analyze whether the enzymatic reactions can generate a significant feedback from enzyme transport onto the substrate profile. We find that this feedback can generate spontaneous spatial patterns in the enzyme distribution, with just a single-step catalytic reaction. However, patterns are formed only for a subclass of transport models. For such models, nonspecific repulsive interactions between the enzyme and the substrate, or attractive interactions between the enzyme and the product, cause the enzyme to accumulate in regions of low substrate concentration. Reactions then amplify local substrate and product fluctuations, causing enzymes to further accumulate where substrate is low. Experimental analysis of this pattern formation process could discriminate between different transport models.

Original languageEnglish
Article number167
JournalCommunications Physics
Volume3
Issue number1
DOIs
StatePublished - 1 Dec 2020

Fingerprint

Dive into the research topics of 'Cross-diffusion induced patterns for a single-step enzymatic reaction'. Together they form a unique fingerprint.

Cite this