Cross-amyloid interaction of Aβ and IAPP at lipid membranes

Janine Seeliger, Florian Evers, Christoph Jeworrek, Shobhna Kapoor, Katrin Weise, Erika Andreetto, Metin Tolan, Aphrodite Kapurniotu, Roland Winter

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


Membrane controlled protein assembly: A study of the amyloid interaction of the islet amyloid polypeptide (IAPP), β-amyloid (Aβ), and a mixture of both with an anionic model raft membrane showed the dominant effect of IAPP on the aggregation process and on the hydrogen-bonding pattern of the assemblies present in the mixture (see picture). The analysis of the interaction of Aβ with IAPP-GI-a non-amyloidogenic IAPP mimic-confirmed these findings.

Original languageEnglish
Pages (from-to)679-683
Number of pages5
JournalAngewandte Chemie International Edition in English
Issue number3
StatePublished - 16 Jan 2012


  • IR spectroscopy
  • X-ray diffraction
  • fibril formation
  • islet amyloid polypeptides
  • β-amyloids


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