Cross-amyloid interaction of Aβ and IAPP at lipid membranes

Janine Seeliger; Florian Evers; Christoph Jeworrek; Shobhna Kapoor; Katrin Weise; Erika Andreetto; Metin Tolan; Aphrodite Kapurniotu; Roland Winter

doi:10.1002/anie.201105877

Cross-amyloid interaction of Aβ and IAPP at lipid membranes

Janine Seeliger, Florian Evers, Christoph Jeworrek, Shobhna Kapoor, Katrin Weise, Erika Andreetto, Metin Tolan, Aphrodite Kapurniotu, Roland Winter

Associate Professorship of Peptid Biochemistry

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Membrane controlled protein assembly: A study of the amyloid interaction of the islet amyloid polypeptide (IAPP), β-amyloid (Aβ), and a mixture of both with an anionic model raft membrane showed the dominant effect of IAPP on the aggregation process and on the hydrogen-bonding pattern of the assemblies present in the mixture (see picture). The analysis of the interaction of Aβ with IAPP-GI-a non-amyloidogenic IAPP mimic-confirmed these findings.

Original language	English
Pages (from-to)	679-683
Number of pages	5
Journal	Angewandte Chemie International Edition in English
Volume	51
Issue number	3
DOIs	https://doi.org/10.1002/anie.201105877
State	Published - 16 Jan 2012

Keywords

IR spectroscopy
X-ray diffraction
fibril formation
islet amyloid polypeptides
β-amyloids

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AU - Evers, Florian

AU - Jeworrek, Christoph

AU - Kapoor, Shobhna

AU - Weise, Katrin

AU - Andreetto, Erika

AU - Tolan, Metin

AU - Kapurniotu, Aphrodite

AU - Winter, Roland

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KW - IR spectroscopy

KW - X-ray diffraction

KW - fibril formation

KW - islet amyloid polypeptides

KW - β-amyloids

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Cross-amyloid interaction of Aβ and IAPP at lipid membranes

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Keywords

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