Abstract
Membrane controlled protein assembly: A study of the amyloid interaction of the islet amyloid polypeptide (IAPP), β-amyloid (Aβ), and a mixture of both with an anionic model raft membrane showed the dominant effect of IAPP on the aggregation process and on the hydrogen-bonding pattern of the assemblies present in the mixture (see picture). The analysis of the interaction of Aβ with IAPP-GI-a non-amyloidogenic IAPP mimic-confirmed these findings.
Original language | English |
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Pages (from-to) | 679-683 |
Number of pages | 5 |
Journal | Angewandte Chemie International Edition in English |
Volume | 51 |
Issue number | 3 |
DOIs | |
State | Published - 16 Jan 2012 |
Keywords
- IR spectroscopy
- X-ray diffraction
- fibril formation
- islet amyloid polypeptides
- β-amyloids