Critical functions for c-Myb at three checkpoints during thymocyte development

Timothy P. Bender, Christopher S. Kremer, Manfred Kraus, Thorsten Buch, Klaus Rajewsky

Research output: Contribution to journalArticlepeer-review

164 Scopus citations

Abstract

The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we identify three points at which c-Myb activity is required for normal T cell differentiation: transition through the double-negative 3 stage, survival of preselection CD4+CD8+ thymocytes, and differentiation of CD4 thymocytes. Thus, c-Myb is essential at several stages during T cell development in the thymus.

Original languageEnglish
Pages (from-to)721-729
Number of pages9
JournalNature Immunology
Volume5
Issue number7
DOIs
StatePublished - Jul 2004
Externally publishedYes

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