Critical assessment of methods of protein structure prediction - Round VII

John Moult, Krzysztof Fidelis, Andriy Kryshtafovych, Burkhard Rost, Tim Hubbard, Anna Tramontano

Research output: Contribution to journalArticlepeer-review

197 Scopus citations

Abstract

This paper is an introduction to the supplemental issue of the journal PROTEINS, dedicated to the seventh CASP experiment to assess the state of the art in protein structure prediction. The paper describes the conduct of the experiment, the categories of prediction included, and outlines the evaluation and assessment procedures. Highlights are improvements in model accuracy rehtive to that obtainable from knowledge of a single best template structure; convergence of the accuracy of models produced by automatic servers toward that produced by human modeling teams; the emergence of methods for predicting the quality of models; and rapidly increasing practical applications of the methods.

Original languageEnglish
Pages (from-to)3-9
Number of pages7
JournalProteins: Structure, Function and Bioinformatics
Volume69
Issue numberSUPPL. 8
DOIs
StatePublished - 2007
Externally publishedYes

Keywords

  • CASP
  • Community wide experiment
  • Protein structure prediction

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