COVID-19 and the Chemical Senses: Supporting Players Take Center Stage

Keiland W. Cooper; David H. Brann; Michael C. Farruggia; Surabhi Bhutani; Robert Pellegrino; Tatsuya Tsukahara; Caleb Weinreb; Paule V. Joseph; Eric D. Larson; Valentina Parma; Mark W. Albers; Linda A. Barlow; Sandeep Robert Datta; Antonella Di Pizio

doi:10.1016/j.neuron.2020.06.032

COVID-19 and the Chemical Senses: Supporting Players Take Center Stage

Keiland W. Cooper, David H. Brann, Michael C. Farruggia, Surabhi Bhutani, Robert Pellegrino, Tatsuya Tsukahara, Caleb Weinreb, Paule V. Joseph, Eric D. Larson, Valentina Parma, Mark W. Albers, Linda A. Barlow, Sandeep Robert Datta, Antonella Di Pizio

Research output: Contribution to journal › Review article › peer-review

244 Scopus citations

Abstract

The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given our limited understanding of SARS-CoV-2 pathogenesis, we propose future experiments to elucidate disease mechanisms and highlight the relevance of this ongoing work to understanding how the virus might alter brain function more broadly.

Original language	English
Pages (from-to)	219-233
Number of pages	15
Journal	Neuron
Volume	107
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2020.06.032
State	Published - 22 Jul 2020
Externally published	Yes

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title = "COVID-19 and the Chemical Senses: Supporting Players Take Center Stage",

abstract = "The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given our limited understanding of SARS-CoV-2 pathogenesis, we propose future experiments to elucidate disease mechanisms and highlight the relevance of this ongoing work to understanding how the virus might alter brain function more broadly.",

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AU - Pellegrino, Robert

AU - Tsukahara, Tatsuya

AU - Weinreb, Caleb

AU - Joseph, Paule V.

AU - Larson, Eric D.

AU - Parma, Valentina

AU - Albers, Mark W.

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AU - Datta, Sandeep Robert

AU - Di Pizio, Antonella

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AB - The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given our limited understanding of SARS-CoV-2 pathogenesis, we propose future experiments to elucidate disease mechanisms and highlight the relevance of this ongoing work to understanding how the virus might alter brain function more broadly.

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COVID-19 and the Chemical Senses: Supporting Players Take Center Stage

Abstract

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