TY - JOUR
T1 - CORUM
T2 - The comprehensive resource of mammalian protein complexes
AU - Ruepp, Andreas
AU - Brauner, Barbara
AU - Dunger-Kaltenbach, Irmtraud
AU - Frishman, Goar
AU - Montrone, Corinna
AU - Stransky, Michael
AU - Waegele, Brigitte
AU - Schmidt, Thorsten
AU - Doudieu, Octave Noubibou
AU - Stümpflen, Volker
AU - Mewes, H. Werner
N1 - Funding Information:
This work was supported by 031U212C BFAM (BMBF) to HWM. Funding to pay the Open Access publication charges for this article was provided by German Research Center for Environmental Health.
PY - 2008/1
Y1 - 2008/1
N2 - Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. The CORUM (http://mips.gsf.de/genre/proj/corum/index.html) database is a collection of experimentally verified mammalian protein complexes. Information is manually derived by critical reading of the scientific literature from expert annotators. Information about protein complexes includes protein complex names, subunits, literature references as well as the function of the complexes. For functional annotation, we use the FunCat catalogue that enables to organize the protein complex space into biologically meaningful subsets. The database contains more than 1750 protein complexes that are built from 2400 different genes, thus representing 12% of the protein-coding genes in human. A web-based system is available to query, view and download the data. CORUM provides a comprehensive dataset of protein complexes for discoveries in systems biology, analyses of protein networks and protein complex-associated diseases. Comparable to the MIPS reference dataset of protein complexes from yeast, CORUM intends to serve as a reference for mammalian protein complexes.
AB - Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. The CORUM (http://mips.gsf.de/genre/proj/corum/index.html) database is a collection of experimentally verified mammalian protein complexes. Information is manually derived by critical reading of the scientific literature from expert annotators. Information about protein complexes includes protein complex names, subunits, literature references as well as the function of the complexes. For functional annotation, we use the FunCat catalogue that enables to organize the protein complex space into biologically meaningful subsets. The database contains more than 1750 protein complexes that are built from 2400 different genes, thus representing 12% of the protein-coding genes in human. A web-based system is available to query, view and download the data. CORUM provides a comprehensive dataset of protein complexes for discoveries in systems biology, analyses of protein networks and protein complex-associated diseases. Comparable to the MIPS reference dataset of protein complexes from yeast, CORUM intends to serve as a reference for mammalian protein complexes.
UR - http://www.scopus.com/inward/record.url?scp=38549163153&partnerID=8YFLogxK
U2 - 10.1093/nar/gkm936
DO - 10.1093/nar/gkm936
M3 - Article
C2 - 17965090
AN - SCOPUS:38549163153
SN - 0305-1048
VL - 36
SP - D646-D650
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - SUPPL. 1
ER -
