TY - JOUR
T1 - Correlation of intratumoral mast cell quantity with psychosocial distress in patients with pancreatic cancer
T2 - the PancStress study
AU - Sitte, Alicia
AU - Goess, Ruediger
AU - Tüfekçi, Tutku
AU - Pergolini, Ilaria
AU - Pfitzinger, Paulo Leonardo
AU - Salvo-Romero, Eloísa
AU - Mota Reyes, Carmen
AU - Tokalov, Sergey
AU - Safak, Okan
AU - Steenfadt, Hendrik
AU - Gürcinar, Ibrahim H.
AU - Yurteri, Ümmügülsüm
AU - Goebel-Stengel, Miriam
AU - Mazzuoli-Weber, Gemma
AU - Stengel, Andreas
AU - Erkan, Mert
AU - Friess, Helmut
AU - Istvanffy, Rouzanna
AU - Ceyhan, Güralp Onur
AU - Demir, Elke
AU - Demir, Ihsan Ekin
N1 - Publisher Copyright:
© 2024. The Author(s).
PY - 2024/11/1
Y1 - 2024/11/1
N2 - Mast cells are commonly found in pancreatic ductal adenocarcinoma (PDAC), yet their role in the disease remains uncertain. Although mast cells have been associated with depression in several diseases, their connection to PDAC in this context remains unclear. This study explored the correlation between mast cells and psychosocial stress in patients with PDAC. Prior to surgery, 40 patients with PDAC (n = 29 primary resected, n = 11 neoadjuvant treated) completed four questionnaires assessing stress and quality of life. Immunostaining was performed on the resected tumor tissue. Spearman analysis was employed to correlate mast cells with distress and neuropeptides serotonin and beta-endorphin serum and tissue levels. Patients with PDAC exhibited elevated levels of distress and worry. Lower number of mast cells within the tumor correlated with greater psychological burden. Among primary resected patients, mast cell count moderately correlated with joy and inversely with worries. Following neoadjuvant chemotherapy, strong inverse correlation was observed between anxiety, depression, and mast cell quantity. No correlation was found between mast cells and serotonin or beta-endorphin levels. In summary, mast cell presence inversely correlates with psychosocial stress, suggesting a link between immune cells and psychological well-being in pancreatic cancer. Targeting mast cells might offer therapeutic avenues for addressing cancer-induced depression and anxiety.
AB - Mast cells are commonly found in pancreatic ductal adenocarcinoma (PDAC), yet their role in the disease remains uncertain. Although mast cells have been associated with depression in several diseases, their connection to PDAC in this context remains unclear. This study explored the correlation between mast cells and psychosocial stress in patients with PDAC. Prior to surgery, 40 patients with PDAC (n = 29 primary resected, n = 11 neoadjuvant treated) completed four questionnaires assessing stress and quality of life. Immunostaining was performed on the resected tumor tissue. Spearman analysis was employed to correlate mast cells with distress and neuropeptides serotonin and beta-endorphin serum and tissue levels. Patients with PDAC exhibited elevated levels of distress and worry. Lower number of mast cells within the tumor correlated with greater psychological burden. Among primary resected patients, mast cell count moderately correlated with joy and inversely with worries. Following neoadjuvant chemotherapy, strong inverse correlation was observed between anxiety, depression, and mast cell quantity. No correlation was found between mast cells and serotonin or beta-endorphin levels. In summary, mast cell presence inversely correlates with psychosocial stress, suggesting a link between immune cells and psychological well-being in pancreatic cancer. Targeting mast cells might offer therapeutic avenues for addressing cancer-induced depression and anxiety.
KW - Anxiety
KW - Depression
KW - Distress
KW - Mast cell
KW - Pancreatic cancer
UR - http://www.scopus.com/inward/record.url?scp=85208290658&partnerID=8YFLogxK
U2 - 10.1038/s41598-024-77010-8
DO - 10.1038/s41598-024-77010-8
M3 - Article
C2 - 39487177
AN - SCOPUS:85208290658
SN - 2045-2322
VL - 14
SP - 26285
JO - Scientific Reports
JF - Scientific Reports
IS - 1
ER -
