Correlation between acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and total body fat content in mammals

Harald J. Geyer; Irene Scheuntert; Karl Rapp; Antonius Kettrup; Friedhelm Korte; Helmut Greim; Karl Rozman

doi:10.1016/0300-483X(90)90081-Q

Correlation between acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and total body fat content in mammals

Harald J. Geyer, Irene Scheuntert, Karl Rapp, Antonius Kettrup, Friedhelm Korte, Helmut Greim, Karl Rozman

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Single oral 30-day LD₅₀s of 2,3,7,8-tetrachlorobibenzo-p-dioxin (TCDD) were correlated with total body fat (TBF) content in various species and strains of laboratory mammals. LD₅₀ values and TBF contents were either obtained from the leterature or determined by experiments. A log (LD₅₀) vs. log (TBF) plot yielded a highly significant linear regression equation (r² = 0.834, P < 0.001, n = 20). It is suggested that this correlation exists for at least two reasons: (1) increasing TBF content in organisms represents an enhanced capacity to remove TCDD from the systemic circulation and (2) different TBF content reflects a differential role and regulation of fat metabolism for various organisms. Extrapolation of this correlation to man suggests that adult humans are among the less sensitive species to the acute toxicity of TCDD.

Original language	English
Pages (from-to)	97-107
Number of pages	11
Journal	Toxicology
Volume	65
Issue number	1-2
DOIs	https://doi.org/10.1016/0300-483X(90)90081-Q
State	Published - 17 Dec 1990
Externally published	Yes

Keywords

2,3,7,8-Tetrachlorodibenzo-p-dioxin
Acute toxicity
Species differences
Total body fat content

Access to Document

10.1016/0300-483X(90)90081-Q

Cite this

@article{62875d9859a74aa2a1c785bf958f97f3,

title = "Correlation between acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and total body fat content in mammals",

abstract = "Single oral 30-day LD50s of 2,3,7,8-tetrachlorobibenzo-p-dioxin (TCDD) were correlated with total body fat (TBF) content in various species and strains of laboratory mammals. LD50 values and TBF contents were either obtained from the leterature or determined by experiments. A log (LD50) vs. log (TBF) plot yielded a highly significant linear regression equation (r2 = 0.834, P < 0.001, n = 20). It is suggested that this correlation exists for at least two reasons: (1) increasing TBF content in organisms represents an enhanced capacity to remove TCDD from the systemic circulation and (2) different TBF content reflects a differential role and regulation of fat metabolism for various organisms. Extrapolation of this correlation to man suggests that adult humans are among the less sensitive species to the acute toxicity of TCDD.",

keywords = "2,3,7,8-Tetrachlorodibenzo-p-dioxin, Acute toxicity, Species differences, Total body fat content",

author = "Geyer, {Harald J.} and Irene Scheuntert and Karl Rapp and Antonius Kettrup and Friedhelm Korte and Helmut Greim and Karl Rozman",

year = "1990",

month = dec,

day = "17",

doi = "10.1016/0300-483X(90)90081-Q",

language = "English",

volume = "65",

pages = "97--107",

journal = "Toxicology",

issn = "0300-483X",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Correlation between acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and total body fat content in mammals

AU - Geyer, Harald J.

AU - Scheuntert, Irene

AU - Rapp, Karl

AU - Kettrup, Antonius

AU - Korte, Friedhelm

AU - Greim, Helmut

AU - Rozman, Karl

PY - 1990/12/17

Y1 - 1990/12/17

N2 - Single oral 30-day LD50s of 2,3,7,8-tetrachlorobibenzo-p-dioxin (TCDD) were correlated with total body fat (TBF) content in various species and strains of laboratory mammals. LD50 values and TBF contents were either obtained from the leterature or determined by experiments. A log (LD50) vs. log (TBF) plot yielded a highly significant linear regression equation (r2 = 0.834, P < 0.001, n = 20). It is suggested that this correlation exists for at least two reasons: (1) increasing TBF content in organisms represents an enhanced capacity to remove TCDD from the systemic circulation and (2) different TBF content reflects a differential role and regulation of fat metabolism for various organisms. Extrapolation of this correlation to man suggests that adult humans are among the less sensitive species to the acute toxicity of TCDD.

AB - Single oral 30-day LD50s of 2,3,7,8-tetrachlorobibenzo-p-dioxin (TCDD) were correlated with total body fat (TBF) content in various species and strains of laboratory mammals. LD50 values and TBF contents were either obtained from the leterature or determined by experiments. A log (LD50) vs. log (TBF) plot yielded a highly significant linear regression equation (r2 = 0.834, P < 0.001, n = 20). It is suggested that this correlation exists for at least two reasons: (1) increasing TBF content in organisms represents an enhanced capacity to remove TCDD from the systemic circulation and (2) different TBF content reflects a differential role and regulation of fat metabolism for various organisms. Extrapolation of this correlation to man suggests that adult humans are among the less sensitive species to the acute toxicity of TCDD.

KW - 2,3,7,8-Tetrachlorodibenzo-p-dioxin

KW - Acute toxicity

KW - Species differences

KW - Total body fat content

UR - http://www.scopus.com/inward/record.url?scp=0025695989&partnerID=8YFLogxK

U2 - 10.1016/0300-483X(90)90081-Q

DO - 10.1016/0300-483X(90)90081-Q

M3 - Article

C2 - 2274972

AN - SCOPUS:0025695989

SN - 0300-483X

VL - 65

SP - 97

EP - 107

JO - Toxicology

JF - Toxicology

IS - 1-2

ER -

Correlation between acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and total body fat content in mammals

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this