Correction to: Pharmacogenomics of clinical response to Natalizumab in multiple sclerosis: a genome-wide multi-centric association study (Journal of Neurology, (2024), 271, 11, (7250-7263), 10.1007/s00415-024-12608-6)

In the original version of this article, author’s name Filippo Martinelli Boneschi was incorrectly written as Filippo Giovanni Martinelli Boneschi. In Table 2, first two columns were missing. The Table 2 which previously appeared as (Table presented.) List of top-associated variants after meta-analysis. The list is obtained upon a clumping procedure (see Methods for details), filtered at p < 5 × 10^–5. The effect allele is the minor allele Position Minor allele Major allele MAF P OR SE I² Gene Genomic context Distance to gene 187,410,850 T C 0.268 1.328E−06 0.582 0.112 0 ncRNA_intronic 68,071,570 T C 0.421 1.678E−06 1.538 0.090 0 Intergenic Dist = 4552; Dist = 15,067 111,037,829 T A 0.251 2.793E−06 0.596 0.111 13 Intergenic Dist = 785,779; Dist = 579,040 20,863,249 G A 0.057 4.804E−06 2.122 0.165 0 Intergenic Dist = 56,715; Dist = 114,557 98,275,102 C G 0.429 6.938E−06 0.650 0.096 34 Intergenic Dist = 171,174; Dist = 10,744 47,775,385 A G 0.230 1.187E−05 1.561 0.102 0 Intronic 21,728,917 A G 0.142 1.191E−05 0.510 0.154 0 Intronic 187,402,360 A G 0.480 1.233E−05 1.496 0.092 0 ncRNA_intronic 115,392,100 A G 0.347 1.259E−05 1.476 0.089 0 Intronic 12,783,519 T C 0.075 1.325E−05 1.934 0.151 0 Intergenic Dist = 107,719; Dist = 19,663 43,181,587 T C 0.080 1.362E−05 1.918 0.150 0 Intergenic Dist = 64,280; Dist = 10,922 79,303,163 G A 0.430 1.475E−05 1.469 0.089 0 Intergenic Dist = 56,599; Dist = 324,572 98,347,870 C G 0.429 1.494E−05 0.676 0.091 57 ncRNA_intronic 27,204,531 C T 0.095 2.087E−05 1.775 0.135 42 Intergenic Dist = 54,515; Dist = 15,604 47,746,678 C G 0.075 2.692E−05 1.839 0.145 29 Exonic 113,293,608 G A 0.411 2.744E−05 1.461 0.090 0 Intergenic Dist = 51,109; Dist = 7750 606,173 C A 0.143 2.862E−05 1.646 0.119 0 Intronic 83,766,280 A C 0.114 2.909E−05 1.739 0.132 48 Intronic 236,647,736 T C 0.233 2.939E−05 1.495 0.096 0 UTR3 NM_145861:c.*1787C>T; NM_080738:c.*1787C>T 93,450,212 A G 0.295 3.023E−05 1.471 0.093 0 Intergenic Dist = 334,599; Dist = 127,459 4,314,917 A G 0.220 3.087E−05 1.523 0.101 0 Intronic 81,279,746 A G 0.271 3.116E−05 1.479 0.094 6.4 Intergenic Dist = 364,485; Dist = 312,780 111,023,899 T C 0.404 3.369E−05 1.441 0.088 0 Intergenic Dist = 771,849; Dist = 592,970 189,243,943 T C 0.413 3.424E−05 1.433 0.087 0 Intergenic Dist = 200,850; Dist = 70,592 114,813,313 C T 0.267 3.459E−05 1.483 0.095 0 Intronic 110,446,839 G A 0.413 3.508E−05 1.433 0.087 0 Intergenic Dist = 7909; Dist = 258,793 177,987,660 G A 0.137 3.639E−05 1.617 0.116 0 ncRNA_intronic 31,271,788 A G 0.072 3.733E−05 1.845 0.148 60 ncRNA_intronic 206,468,850 T G 0.419 4.007E−05 1.433 0.088 0 Intronic 54,692,961 G A 0.116 4.025E−05 1.652 0.122 6.9 Intergenic Dist = 438,021; Dist = 18,608 141,938,633 C T 0.069 4.217E−05 1.890 0.155 74 Intergenic Dist = 16,509; Dist = 1923 81,959,114 T C 0.499 4.222E−05 0.697 0.088 5.8 Intergenic Dist = 343,363; Dist = 176,860 158,058,545 T C 0.436 4.257E−05 1.455 0.092 0 Intronic 180,648,923 C T 0.480 4.571E−05 0.699 0.088 0 Intergenic Dist = 1,737,019; Dist = 1,336,320 83,182,354 A G 0.299 4.605E−05 1.458 0.093 0 Intronic 10,732,844 G A 0.050 4.841E−05 2.053 0.177 53 Intronic 130,499,623 G A 0.096 4.929E−05 1.749 0.138 42 Intergenic Dist = 383,633; Dist = 211,474 156,675,608 A C 0.135 4.934E−05 1.642 0.122 0 Intergenic Dist = 17,399; Dist = 4565 50,679,081 T G 0.372 4.966E−05 1.448 0.091 0 Intergenic Dist = 661,439; Dist = 2158 For each variant, the gene harboring it or nearest gene(s) are reported, together with its genomic context and distance in base-pairs from the nearest genes, as of ANNOVAR annotation Abbreviations: MAF (Minor Allele Frequency), P (p value from fixed-effect meta-analysis), OR (odds ratio from fixed-effects meta-analysis), SE (standard error), I² (heterogeneity index) but Table 2 should have appeared as shown below. (Table presented.) List of top associated variants after meta-analysis SNP Chromosome Position Minor allele Major allele MAF P OR SE I² Gene Genomic context Distance to gene rs11132400 4 187410850 T C 0.268 1.328E−06 0.582 0.112 0 ncRNA_intronic rs12885261 14 68071570 T C 0.421 1.678E−06 1.538 0.090 0 Intergenic dist = 4552; dist = 15,067 rs1323374 9 111037829 T A 0.251 2.793E−06 0.596 0.111 13 Intergenic dist = 785,779; dist = 579,040 rs61166479 13 20863249 G A 0.057 4.804E−06 2.122 0.165 0 Intergenic dist = 56,715; dist = 114,557 rs1032954 15 98275102 C G 0.429 6.938E−06 0.650 0.096 34 Intergenic dist = 171,174; dist = 10,744 rs75772884 15 47775385 A G 0.230 1.187E−05 1.561 0.102 0 Intronic rs34736466 3 21728917 A G 0.142 1.191E−05 0.510 0.154 0 Intronic rs12649886 4 187402360 A G 0.480 1.233E−05 1.496 0.092 0 ncRNA_intronic rs13073759 3 115392100 A G 0.347 1.259E−05 1.476 0.089 0 Intronic rs2977141 8 12783519 T C 0.075 1.325E−05 1.934 0.151 0 Intergenic dist = 107,719; dist = 19,663 rs7286822 22 43181587 T C 0.080 1.362E−05 1.918 0.150 0 Intergenic dist = 64,280; dist = 10,922 rs9922330 16 79303163 G A 0.430 1.475E−05 1.469 0.089 0 Intergenic dist = 56,599; dist = 324,572 rs72752604 15 98347870 C G 0.429 1.494E−05 0.676 0.091 57 ncRNA_intronic rs1815323 10 27204531 C T 0.095 2.087E−05 1.775 0.135 42 Intergenic dist = 54,515; dist = 15,604 rs10789505 1 47746678 C G 0.075 2.692E−05 1.839 0.145 29 Exonic rs9577824 13 113293608 G A 0.411 2.744E−05 1.461 0.090 0 Intergenic dist = 51,109; dist = 7750 rs2159600 12 606173 C A 0.143 2.862E−05 1.646 0.119 0 Intronic rs12806160 11 83766280 A C 0.114 2.909E−05 1.739 0.132 48 Intronic rs6428955 1 236647736 T C 0.233 2.939E−05 1.495 0.096 0 UTR3 NM_145861:c.*1787C > T; NM_080738:c.*1787C > T rs1072934 8 93450212 A G 0.295 3.023E−05 1.471 0.093 0 Intergenic dist = 334,599; dist = 127,459 rs1217680 8 4314917 A G 0.220 3.087E−05 1.523 0.101 0 Intronic rs12428095 13 81279746 A G 0.271 3.116E−05 1.479 0.094 6.4 Intergenic dist = 364,485; dist = 312,780 rs10739255 9 111023899 T C 0.404 3.369E−05 1.441 0.088 0 Intergenic dist = 771,849; dist = 592,970 rs6803844 3 189243943 T C 0.413 3.424E−05 1.433 0.087 0 Intergenic dist = 200,850; dist = 70,592 rs7960396 12 114813313 C T 0.267 3.459E−05 1.483 0.095 0 Intronic rs1414319 13 110446839 G A 0.413 3.508E−05 1.433 0.087 0 Intergenic dist = 7909; dist = 258,793 rs7537568 1 177987660 G A 0.137 3.639E−05 1.617 0.116 0 ncRNA_intronic rs112417083 12 31271788 A G 0.072 3.733E−05 1.845 0.148 60 ncRNA_intronic rs13031793 2 206468850 T G 0.419 4.007E−05 1.433 0.088 0 Intronic rs9475026 6 54692961 G A 0.116 4.025E−05 1.652 0.122 6.9 Intergenic dist = 438,021; dist = 18,608 rs59801030 7 141938633 C T 0.069 4.217E−05 1.890 0.155 74 Intergenic dist = 16,509; dist = 1923 rs10040233 5 81959114 T C 0.499 4.222E−05 0.697 0.088 5.8 Intergenic dist = 343,363; dist = 176,860 rs618823 6 158058545 T C 0.436 4.257E−05 1.455 0.092 0 Intronic rs4444875 4 180648923 C T 0.480 4.571E−05 0.699 0.088 0 Intergenic dist = 1,737,019; dist = 1,336,320 rs2068076 11 83182354 A G 0.299 4.605E−05 1.458 0.093 0 Intronic rs76674464 16 10732844 G A 0.050 4.841E−05 2.053 0.177 53 Intronic rs12265034 10 130499623 G A 0.096 4.929E−05 1.749 0.138 42 Intergenic dist = 383,633; dist = 211,474 rs6838876 4 156675608 A C 0.135 4.934E−05 1.642 0.122 0 Intergenic dist = 17,399; dist = 4565 rs1923523 6 50679081 T G 0.372 4.966E−05 1.448 0.091 0 Intergenic dist = 661,439; dist = 2158 The list is obtained upon a clumping procedure (see Methods for details), filtered at p < 5 × 10⁻⁵.