Correction for Mechanical Inaccuracies in a Scanning Talbot-Lau Interferometer

Wolfgang Noichl, Fabio De Marco, Konstantin Willer, Theresa Urban, Manuela Frank, Rafael Schick, Bernhard Gleich, Lorenz Hehn, Alex Gustschin, Pascal Meyer, Thomas Koehler, Ingo Maack, Klaus Jurgen Engel, Bernd Lundt, Bernhard Renger, Alexander Fingerle, Daniela Pfeiffer, Ernst Rummeny, Julia Herzen, Franz Pfeiffer

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Grating-based X-ray phase-contrast and in particular dark-field radiography are promising new imaging modalities for medical applications. Currently, the potential advantage of dark-field imaging in early-stage diagnosis of pulmonary diseases in humans is being investigated. These studies make use of a comparatively large scanning interferometer at short acquisition times, which comes at the expense of a significantly reduced mechanical stability as compared to tabletop laboratory setups. Vibrations create random fluctuations of the grating alignment, causing artifacts in the resulting images. Here, we describe a novel maximum likelihood method for estimating this motion, thereby preventing these artifacts. It is tailored to scanning setups and does not require any sample-free areas. Unlike any previously described method, it accounts for motion in between as well as during exposures.

Original languageEnglish
Pages (from-to)28-38
Number of pages11
JournalIEEE Transactions on Medical Imaging
Issue number1
StatePublished - 1 Jan 2024


  • Image enhancement/restoration (noise and artifact reduction)
  • X-ray imaging and computed tomography
  • image reconstruction-iterative methods


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