Copper-catalyzed trifluoromethylation of aryl- and vinylboronic acids with generation of CF3-radicals

Yang Li, Lipeng Wu, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

165 Scopus citations

Abstract

The selective trifluoromethylation of aryl- and vinylboronic acids proceeds smoothly with CF3SO2Na (Langlois reagent) in the presence of copper catalysts and t-BuOOH. Therefore, the method relies both on transition metal catalysis and selective radical reactions. Advantageously, the protocol can be performed at room temperature under an air atmosphere and avoids the issue of poor regioselectivity.

Original languageEnglish
Pages (from-to)2628-2630
Number of pages3
JournalChemical Communications
Volume49
Issue number26
DOIs
StatePublished - 5 Mar 2013
Externally publishedYes

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