Coordinating the impact of structural genomics on the human α-helical transmembrane proteome

Ursula Pieper; Avner Schlessinger; Edda Kloppmann; Geoffrey A. Chang; James J. Chou; Mark E. Dumont; Brian G. Fox; Petra Fromme; Wayne A. Hendrickson; Michael G. Malkowski; Douglas C. Rees; David L. Stokes; Michael H.B. Stowell; Michael C. Wiener; Burkhard Rost; Robert M. Stroud; Raymond C. Stevens; Andrej Sali

doi:10.1038/nsmb.2508

Coordinating the impact of structural genomics on the human α-helical transmembrane proteome

Ursula Pieper
, Avner Schlessinger
, Edda Kloppmann
, Geoffrey A. Chang
, James J. Chou
, Mark E. Dumont
, Brian G. Fox
, Petra Fromme
, Wayne A. Hendrickson
, Michael G. Malkowski
, Douglas C. Rees
, David L. Stokes
, Michael H.B. Stowell
, Michael C. Wiener
, Burkhard Rost
, Robert M. Stroud
, Raymond C. Stevens
, Andrej Sali

Informatics 12 - Chair of Bioinformatics

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

Given the recent successes in determining membrane-protein structures, we explore the tractability of determining representatives for the entire human membrane proteome. This proteome contains 2,925 unique integral α-helical transmembrane-domain sequences that cluster into 1,201 families sharing more than 25% sequence identity. Structures of 100 optimally selected targets would increase the fraction of modelable human α-helical transmembrane domains from 26% to 58%, providing structure and function information not otherwise available.

Original language	English
Pages (from-to)	135-138
Number of pages	4
Journal	Nature Structural and Molecular Biology
Volume	20
Issue number	2
DOIs	https://doi.org/10.1038/nsmb.2508
State	Published - Feb 2013

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Pieper, U., Schlessinger, A., Kloppmann, E., Chang, G. A., Chou, J. J., Dumont, M. E., Fox, B. G., Fromme, P., Hendrickson, W. A., Malkowski, M. G., Rees, D. C., Stokes, D. L., Stowell, M. H. B., Wiener, M. C., Rost, B., Stroud, R. M., Stevens, R. C., & Sali, A. (2013). Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nature Structural and Molecular Biology, 20(2), 135-138. https://doi.org/10.1038/nsmb.2508

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title = "Coordinating the impact of structural genomics on the human α-helical transmembrane proteome",

abstract = "Given the recent successes in determining membrane-protein structures, we explore the tractability of determining representatives for the entire human membrane proteome. This proteome contains 2,925 unique integral α-helical transmembrane-domain sequences that cluster into 1,201 families sharing more than 25\% sequence identity. Structures of 100 optimally selected targets would increase the fraction of modelable human α-helical transmembrane domains from 26\% to 58\%, providing structure and function information not otherwise available.",

author = "Ursula Pieper and Avner Schlessinger and Edda Kloppmann and Chang, \{Geoffrey A.\} and Chou, \{James J.\} and Dumont, \{Mark E.\} and Fox, \{Brian G.\} and Petra Fromme and Hendrickson, \{Wayne A.\} and Malkowski, \{Michael G.\} and Rees, \{Douglas C.\} and Stokes, \{David L.\} and Stowell, \{Michael H.B.\} and Wiener, \{Michael C.\} and Burkhard Rost and Stroud, \{Robert M.\} and Stevens, \{Raymond C.\} and Andrej Sali",

year = "2013",

month = feb,

doi = "10.1038/nsmb.2508",

language = "English",

volume = "20",

pages = "135--138",

journal = "Nature Structural and Molecular Biology",

issn = "1545-9993",

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Pieper, U, Schlessinger, A, Kloppmann, E, Chang, GA, Chou, JJ, Dumont, ME, Fox, BG, Fromme, P, Hendrickson, WA, Malkowski, MG, Rees, DC, Stokes, DL, Stowell, MHB, Wiener, MC, Rost, B, Stroud, RM, Stevens, RC & Sali, A 2013, 'Coordinating the impact of structural genomics on the human α-helical transmembrane proteome', Nature Structural and Molecular Biology, vol. 20, no. 2, pp. 135-138. https://doi.org/10.1038/nsmb.2508

TY - JOUR

T1 - Coordinating the impact of structural genomics on the human α-helical transmembrane proteome

AU - Pieper, Ursula

AU - Schlessinger, Avner

AU - Kloppmann, Edda

AU - Chang, Geoffrey A.

AU - Chou, James J.

AU - Dumont, Mark E.

AU - Fox, Brian G.

AU - Fromme, Petra

AU - Hendrickson, Wayne A.

AU - Malkowski, Michael G.

AU - Rees, Douglas C.

AU - Stokes, David L.

AU - Stowell, Michael H.B.

AU - Wiener, Michael C.

AU - Rost, Burkhard

AU - Stroud, Robert M.

AU - Stevens, Raymond C.

AU - Sali, Andrej

PY - 2013/2

Y1 - 2013/2

N2 - Given the recent successes in determining membrane-protein structures, we explore the tractability of determining representatives for the entire human membrane proteome. This proteome contains 2,925 unique integral α-helical transmembrane-domain sequences that cluster into 1,201 families sharing more than 25% sequence identity. Structures of 100 optimally selected targets would increase the fraction of modelable human α-helical transmembrane domains from 26% to 58%, providing structure and function information not otherwise available.

AB - Given the recent successes in determining membrane-protein structures, we explore the tractability of determining representatives for the entire human membrane proteome. This proteome contains 2,925 unique integral α-helical transmembrane-domain sequences that cluster into 1,201 families sharing more than 25% sequence identity. Structures of 100 optimally selected targets would increase the fraction of modelable human α-helical transmembrane domains from 26% to 58%, providing structure and function information not otherwise available.

UR - https://www.scopus.com/pages/publications/84873535031

U2 - 10.1038/nsmb.2508

DO - 10.1038/nsmb.2508

M3 - Review article

C2 - 23381628

AN - SCOPUS:84873535031

SN - 1545-9993

VL - 20

SP - 135

EP - 138

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

IS - 2

ER -

Coordinating the impact of structural genomics on the human α-helical transmembrane proteome

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