Cooperative transition-metal and chiral Brønsted acid catalysis: Enantioselective hydrogenation of imines to form amines

Shaolin Zhou, Steffen Fleischer, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

221 Scopus citations

Abstract

Control with an iron hand: A broad range of ketimines underwent enantioselective hydrogenation in the presence of a chiral Brønsted catalyst and a well-defined nonchiral iron catalyst (see scheme). This procedure constitutes an attractive and environmentally favorable alternative to well-established asymmetric hydrogenation reactions with precious-metal catalysts.

Original languageEnglish
Pages (from-to)5120-5124
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume50
Issue number22
DOIs
StatePublished - 23 May 2011
Externally publishedYes

Keywords

  • asymmetric catalysis
  • hydrogenation
  • imines
  • iron
  • organocatalysis

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