Cooperative catalysis with iron and a chiral brønsted acid for asymmetric reductive amination of ketones

Shaolin Zhou, Steffen Fleischer, Haijun Jiao, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

The direct asymmetric reductive amination (DARA) of ketones with anilines is described by combining a chiral Brønsted acid (TRIP) and the non-chiral Knçlker iron complex as the catalyst system. In situ-formed imines are reduced with molecular hydrogen to give chiral amines in high yields (90%) and enantioselectivities of up to 99% ee.

Original languageEnglish
Pages (from-to)3451-3455
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume356
Issue number16
DOIs
StatePublished - 21 Sep 2014
Externally publishedYes

Keywords

  • Amines
  • Brønsted acids
  • Catalysis
  • Iron
  • Reductive amination

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