Cooperative catalysis by palladium and a chiral phosphoric acid: Enantioselective amination of racemic allylic alcohols

Debasis Banerjee, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Cooperative catalysis by [Pd(dba)2] and the chiral phosphoric acid BA1 in combination with the phosphoramidite ligand L8 enabled the efficient enantioselective amination of racemic allylic alcohols with a variety of functionalized amines. This catalytic protocol is highly regio-and stereoselective (up to e.r. 96:4) and furnishes valuable chiral amines in almost quantitative yield.

Original languageEnglish
Pages (from-to)13049-13053
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume53
Issue number48
DOIs
StatePublished - 24 Nov 2014
Externally publishedYes

Keywords

  • Allylic alcohols
  • Asymmetric amination
  • Chiral phosphoric acids
  • Palladium
  • Phosphoramidite ligands

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