Convenient synthesis of 68Ga-labeled gadolinium(III) complexes: Towards bimodal responsive probes for functional imaging with PET/MRI

Johannes Notni; Petr Hermann; Isabel Dregely; Hans Jürgen Wester

doi:10.1002/chem.201302751

Convenient synthesis of ⁶⁸Ga-labeled gadolinium(III) complexes: Towards bimodal responsive probes for functional imaging with PET/MRI

Johannes Notni
, Petr Hermann
, Isabel Dregely
, Hans Jürgen Wester

Chair of Pharmaceutical Radiochemistry

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A killer application? Recently, fully integrated full-body positron-emission tomography (PET) and magnetic-resonance imaging (MRI) scanners were brought to market, allowing simultaneous recording of complementary 3D data sets. By using bimodal PET/MRI probes (see figure), in vivo 3D mapping of various parameters with medical relevance could become feasible.

Original language	English
Pages (from-to)	12602-12606
Number of pages	5
Journal	Chemistry - A European Journal
Volume	19
Issue number	38
DOIs	https://doi.org/10.1002/chem.201302751
State	Published - 16 Sep 2013

Keywords

contrast agents
gallium-68
macrocyclic ligands
magnetic resonance imaging
positron emission tomography
radiopharmaceuticals

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10.1002/chem.201302751

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title = "Convenient synthesis of 68Ga-labeled gadolinium(III) complexes: Towards bimodal responsive probes for functional imaging with PET/MRI",

abstract = "A killer application? Recently, fully integrated full-body positron-emission tomography (PET) and magnetic-resonance imaging (MRI) scanners were brought to market, allowing simultaneous recording of complementary 3D data sets. By using bimodal PET/MRI probes (see figure), in vivo 3D mapping of various parameters with medical relevance could become feasible.",

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AU - Dregely, Isabel

AU - Wester, Hans Jürgen

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KW - gallium-68

KW - macrocyclic ligands

KW - magnetic resonance imaging

KW - positron emission tomography

KW - radiopharmaceuticals

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Convenient synthesis of ⁶⁸Ga-labeled gadolinium(III) complexes: Towards bimodal responsive probes for functional imaging with PET/MRI

Abstract

Keywords

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